Membrane separation technology is applied to the process analysis of ginkgo biloba extraction flavonoids.

Flavonoids in Ginkgo biloba are one of the main effective parts, Ginkgo flavonoids have a strong role in removing free fundamentals in cells, can reduce the oxidation metabolism of cells, the brain and limb arterial blood loss caused by a series of cardiovascular diseases have a clear and unique effect. The content of flavonoids in Ginkgo biloba accounted for 0.8% to 3.5% of dry leaves, which varies with variety, geographical distribution and seasonal variation. The traditional extraction process is more mature, the route is as follows:
raw material pre-treatment leaching
filtration
filtration concentration and centrifugation
chromatography
searing concentrate
drying
Gink almond leaffinished product
traditional extraction process description:
raw materials: to pick Ginkgo biloba as raw material.
: Put the raw materials in a
oven
to dry at a temperature of 60 to 65 degrees C, and then crush them with a high-speed
tissue
mixer.
leaching, filtration: 1:9 (W/V) to add 70% ethanol, 70 to 75 degrees C water bath, stirring and immersion for 2 hours, by gauze filtration, filter slag to 1:6 to add 70% ethanol, 70 to 75 degrees C water bath, stirring stirring immersion for 2 hours, filtered by gauze, combined leaching liquid.
filtering: using the filtration device for decompression and filtration treatment, collection of filter fluid, discarding the slag.
: Ethanol is recovered with a decompression distillation device to obtain the concentrate.
centrifugation: concentrate plus 3 times distilled water naturally subside for 4 to 6 hours, at a temperature of 16 degrees C, 12000r/min under the condition of centrifugation separation 15min, to clarify the transparent centrifuge.
chromatography separation: according to the resin volume of 4 times the amount of centrifugal liquid over polyamide column, and then washed with distilled water through the column, until the outflow liquid is clear, and then added with the resin and other volume of 25% ethanol washing, dried with 80% ethanol washed away, collecting darker parts of the color.
concentrate, dry: decompression concentrate, vacuum low temperature drying, get pale yellow Ginkgo biloba extract finished, its flavonoid content can be stabilized at 33%.
Traditional extraction process analysis:
in the leaching, filtration process, the traditional process consumes a large number of
organic
reagents
, complex operation, expensive equipment, reagent loss is large, direct water extraction, with low cost, simple extraction process characteristics.
in the filtration process, the filter medium accuracy is low, and belongs to the dead-end filtration, the quality of the filter fluid is unstable, will bring in more impurities, and the yield is low, the use of a tube ceramic membrane system can directly high temperature leachate for misflow filtration, to be clarified transparent water pick-up, the pumping and centrifugal separation of the two processes into one. According to the requirements of chromatography separation on the concentration of water pick-up fluid, the reel organic membrane system can be used for concentration, and the resin wasculation can be further concentrated, thus greatly reducing the production cost and improving the yield. Its concentrate is then reduced pressure concentrate, vacuum low temperature drying.
improved extraction process is as follows:
raw material pre-treatment leaching ceramic membrane filter reel film concentrated chromatography separation concentrated dry Ginkgo biloba extract finished
.