Meng Laisheng’s research group reveals the molecular mechanism by which sucrose and glucose signaling molecules regulate the transition of plants from infancy to adulthood

Meng Laisheng’s research group reveals the molecular mechanism by which sucrose and glucose signaling molecules regulate the transition of plants from infancy to adulthood

Meng Laisheng’s research group reveals the molecular mechanism of sucrose and glucose signaling molecules regulating the transition of plants from childhood to adulthood.

On July 13, 2021, Meng Laisheng's research group from the School of Life Sciences, Jiangsu Normal University published a study titled "Glucose and Sucrose Signaling Modules Regulate the Arabidopsis Juvenile-to-Adult Phase Transition" online in Cell Reports in the form of a long article Thesis
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This paper reveals that sucrose and glucose signaling molecules regulate the molecular mechanism of the transition from childhood to adult through the PAP1-SPL9 module and CINV1-glucose-HXK1-miR156-SPL9-PAP1-CINV1-glucose feedback promotion loop, respectively
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Associate Professor Meng Laisheng from the School of Life Sciences, Jiangsu Normal University, and postgraduate students Bao Qinxin, Mu Xinrong, and Tong Chen are the co-first authors of the paper, and Associate Professor Meng Laisheng is the corresponding author
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Research Background

Research Background

As one of the main nutrients of plants, sucrose and glucose, the main photosynthetic products of plants, play a very important role in plant growth, development, stress, and metabolism
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In most cases, sucrose and glucose regulate plant growth and development in the form of nutritional signals

The transition from juvenile to adulthood is a critical stage for plants to complete their life cycle, providing a nutritional basis for future reproductive growth
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With the growth and development of plants, sugar signaling promotes the transition of plants from childhood to adulthood by inhibiting small RNA molecules such as miRNA156

Main result

Main result

1.
Cytosolic translocator (CINV1/2) is a key enzyme that irreversibly decomposes sucrose into glucose in plants, and it can provide endogenous glucose
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The study found that knocking out the CINV1/2 gene can produce a phenotype that strongly hinders the transition from childhood to adulthood, that is, knockout mutants of this gene have serious developmental disorders

2.
A glucose feedback promotion loop (CINV1-glucose-HXK1-miR156-SPL9-PAP1-CINV1-glucose) was discovered
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Glucose signals regulate the transition of plants from childhood to adulthood through this ring

3.
A PAP1-SPL9 module was discovered, through which sucrose directly regulates the transition of plants from infancy to adulthood
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Previous people have reported that sucrose, but not other sugars, can specifically induce the expression of PAP1 transcription factor

In summary, this study reveals that plants use sucrose and glucose to promote their transition from childhood to adulthood
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These two sugar signal molecules regulate the plant's phase transition through different pathways

This paper was funded by the General Project of the National Natural Science Foundation of China and the Xuzhou Agricultural Science and Technology (Agricultural High-tech Research Project) project
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Professor Loake from the University of Edinburgh provided a lot of help in writing, editing and polishing the paper

Related paper information: https://doi.

https://doi.
org/10.
1016/j.
celrep.
2021.
109348 https://doi.
org/10.
1016/j.
celrep.
2021.
109348