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Propofol is the most widely used anesthetic.
Previous studies did not include the thalamus, which is a key link in regulating cortical activity.
The laboratory of the Picower Institute of Learning and Memory at MIT has conducted a unique in-depth and detailed study on how the commonly used anesthetic propofol causes unconsciousness.
A unique in-depth and detailed study of how the commonly used anesthetic propofol causes unconsciousness has been carried out.
In order to study the effects of propofol on the cortex and thalamus, the researchers implanted catheters through vascular access or computer-controlled infusion tubes, and treated four rhesus monkeys with propofol.
Blood vessel
Research on how anesthetics change brain rhythms can directly affect the safety of patients, because these brain rhythms are easy to see on the electroencephalogram in the operating room.
The main finding of the study is that the entire cerebral cortex has a very slow rhythm feature, which provides a model for directly measuring when subjects enter an unconscious state after propofol administration, and they are maintained in this state What is the degree and how quickly they might wake up once the propofol administration is over .
medsci.
Synchronous changes in the hypothalamus - cortex in the awake and unconscious states .
Synchronous changes in the hypothalamus - cortex in the awake and unconscious states .
In addition to the common synchronicity at very slow frequencies, the research team also noticed other signs of unconsciousness in the data.
The research team further showed that stimulating the thalamus with high-frequency current pulses (180Hz) can eliminate the effects of propofol.
The extensive kinetics observed after the administration of propofol indicate that the unconsciousness caused by propofol is a multifactorial process.
Original source :
André M Bastos et al, Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation,eLife (2021).
Bastos et Al M André, Neural Effects of through interfering with the ITS REVERSAL-induced unconsciousness and the using the thalamic stimulation, eLife (2021).
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