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Abstract: Chen Wei and Wang Gang from the School of Food Science and Technology of Jiangnan University and Professor John F.
Cryan from the University of Cork in Ireland published an online publication entitled "Unravelling the Microbial Mechanisms Underlying the Psychobiotic Potential" in the international journal "Molecular Nutrition & Food Research" (IF=5.
309) of a Bifidobacterium breveStrain" research article.
Associate Professor Wang Gang and Professor John F.
Cryan are the co-corresponding authors.
Keywords: Psychobiotics, Stress, Depression, Genomics, Metabolomics.
The antidepressant effects of Psychobiotics have been confirmed in preclinical and clinical studies, but the molecular mechanism of their effects is still unclear.
In order to solve this problem, this article studied the genomic characteristics and metabolic characteristics of the mental probiotic Bifidobacterium breve CCFM1025, as well as the regulation of the intestinal flora and its metabolites.
Unlike the negative control Bifidobacterium breve FHLJDQ3M5, CCFM1025 significantly reduced the depression-like behavior and nervous system dysfunction in chronically stressed mice.
Compared with the genome of FHLJDQ3M5, CCFM1025 has more genes encoding glycoside hydrolase, which means that CCFM1025 has better carbohydrate utilization capacity and environmental adaptability in the intestine.
CCFM1025 also produces higher levels of neuroactive metabolites, including hypoxanthine, tryptophan, and nicotinate.
The use of CCFM1025 reshaped the gut microbiome of chronically stressed mice, producing higher levels of cecal xanthines, tryptophan and short-chain fatty acids, and enhanced the fatty acid and tryptophan in the intestine-brain communication pathway Biosynthetic capacity (confirmed by gut-brain module analysis and metabolome enrichment analysis).
In summary, the genome and metabolome characteristics of glycoside hydrolase and neuroactive metabolites may determine the antidepressant effect of Bifidobacterium breve CCFM1025, which also provides guidance for the future development of new psychotropic drugs and dietary supplements.
WILEY paper information: Unraveling the Microbial Mechanisms Underlying the Psychobiotic Potential of a Bifidobacterium breve StrainPeijun Tian, Thomas FS Bastiaanssen, Linhong Song, Bin Jiang, Xu Zhang, Jianxin Zhao, Hao Zhang, Wei Chen, John F.
Cryan, Gang Wang Molecular Nutrition & Food ResearchDOI: 10.
1002/mnfr.
202000704 Click "Read the original text" in the lower left corner to view the original text of the paper.
Molecular Nutrition & Food Research Journal Introduction Wiley's Molecular Nutrition & Food Research journal was founded in 1957, focusing on publishing cutting-edge research work on health, safety and all related molecular nutrition fields.
The manuscript covers topics including nutritional biology, nutrigenomics, metabolomics, etc.
The 2020 impact factor is 5.
31. Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
Cryan from the University of Cork in Ireland published an online publication entitled "Unravelling the Microbial Mechanisms Underlying the Psychobiotic Potential" in the international journal "Molecular Nutrition & Food Research" (IF=5.
309) of a Bifidobacterium breveStrain" research article.
Associate Professor Wang Gang and Professor John F.
Cryan are the co-corresponding authors.
Keywords: Psychobiotics, Stress, Depression, Genomics, Metabolomics.
The antidepressant effects of Psychobiotics have been confirmed in preclinical and clinical studies, but the molecular mechanism of their effects is still unclear.
In order to solve this problem, this article studied the genomic characteristics and metabolic characteristics of the mental probiotic Bifidobacterium breve CCFM1025, as well as the regulation of the intestinal flora and its metabolites.
Unlike the negative control Bifidobacterium breve FHLJDQ3M5, CCFM1025 significantly reduced the depression-like behavior and nervous system dysfunction in chronically stressed mice.
Compared with the genome of FHLJDQ3M5, CCFM1025 has more genes encoding glycoside hydrolase, which means that CCFM1025 has better carbohydrate utilization capacity and environmental adaptability in the intestine.
CCFM1025 also produces higher levels of neuroactive metabolites, including hypoxanthine, tryptophan, and nicotinate.
The use of CCFM1025 reshaped the gut microbiome of chronically stressed mice, producing higher levels of cecal xanthines, tryptophan and short-chain fatty acids, and enhanced the fatty acid and tryptophan in the intestine-brain communication pathway Biosynthetic capacity (confirmed by gut-brain module analysis and metabolome enrichment analysis).
In summary, the genome and metabolome characteristics of glycoside hydrolase and neuroactive metabolites may determine the antidepressant effect of Bifidobacterium breve CCFM1025, which also provides guidance for the future development of new psychotropic drugs and dietary supplements.
WILEY paper information: Unraveling the Microbial Mechanisms Underlying the Psychobiotic Potential of a Bifidobacterium breve StrainPeijun Tian, Thomas FS Bastiaanssen, Linhong Song, Bin Jiang, Xu Zhang, Jianxin Zhao, Hao Zhang, Wei Chen, John F.
Cryan, Gang Wang Molecular Nutrition & Food ResearchDOI: 10.
1002/mnfr.
202000704 Click "Read the original text" in the lower left corner to view the original text of the paper.
Molecular Nutrition & Food Research Journal Introduction Wiley's Molecular Nutrition & Food Research journal was founded in 1957, focusing on publishing cutting-edge research work on health, safety and all related molecular nutrition fields.
The manuscript covers topics including nutritional biology, nutrigenomics, metabolomics, etc.
The 2020 impact factor is 5.
31. Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
