Molecular Cell: Scientists have developed new techniques to reveal hidden genomes

Scientists at the Duke-Nuancer University School of Medicine and their collaborators have used an innovative new technique to identify thousands of previously unknown DNA sequences in the human genome that encode microproteins and peptides

Dr.

Scientists have been trying to identify smorfs and the small peptides they encode, because destroying these smorfs can lead to disease

"Many of the current datasets don't provide enough detailed information to identify smorfs in RNA," Dr.

Chothani and her colleagues in Singapore, Germany, the United Kingdom and Australia published articles in the journal Molecular Cell describing a method they developed to address these problems

Analysis of these data identified nearly 8,000 smorfs

Owen Rackham, the study's senior author and an assistant professor from the CVMD project, said, "The genome is full of smorf

Professor Patrick Casey, Senior Associate Dean at Duke University-National University of Singapore, said: "As healthcare systems evolve to not only treat disease, but also prevent disease, identifying potential new targets for disease research and drug development could open avenues

Article title

A high-resolution map of human RNA translation