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Enterovirus D68 (EV-D68) is a member of the D family of enteroviruses of the Picornaviridae family, and is closely related to severe respiratory infections and acute fragile myelitis (AFM) in children
Huang Zhong's team prepared two monoclonal antibodies 2H12 and 8F12 against EV-D68 virus-like particles
Cong Yao's team analyzed the cryo-EM structure of the complex formed by the antibody 8F12 combined with the EV-D68 mature virus, with a resolution of 2.
In summary, this study has developed a pair of unique EV-D68 neutralizing monoclonal antibodies, revealing that their epitopes are similar, but their binding properties, neutralizing properties, and mechanism of action are different
Zhang Chao, associate researcher at the Shanghai Pasteur Institute, Xu Cong, a doctoral student at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, and Dai Wenlong, a doctoral student from the Shanghai Pasteur Institute, are the first authors of this article
Article link: https://
(A) The neutralization spectrum difference of monoclonal antibodies 2H12, 8F12 and their combinations