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More than 80% of patients' tumors have shrunk!

 Last Update: 2021-12-29
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Shi Bei

On December 10, Infinity announced at the San Antonio Breast Cancer Symposium (SABCS) that the PI3Kγ inhibitor eganelisib combined with Atelizumab (Tecentriq) and Albumin Paclitaxel (Abraxane) as the first-line treatment of metastatic triple-negative breast cancer (TNBC) Updated data for the Phase II MARIO-3 study

Eganelisib is a first-in-class highly selective oral PI3Kγ inhibitor

At a median follow-up time of 9.

The disease control rate (DCR) of PD-L1(+) tumor patients was 92.

In PD-L1(+) patients, the median PFS of triple therapy was 11.

The most common grade 3 or higher treatment-related TEAEs in the study were liver adverse reactions (18%); neutropenia (16%); skin-related adverse reactions (12%); fatigue, diarrhea, and peripheral sensations Neuropathy (6% each); vomiting and weight loss (2% each)

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