Among the 20 types of cancers including lung cancer, stomach cancer, liver cancer, breast cancer, and prostate cancer, more than 97% of people are susceptible to at least one cancer, and the risk of cancer is significantly increased for people with medium to high genetic risk and unhealthy lifestyles
Recently, Shen Hongbing, an academician of the Chinese Academy of Engineering , and a research team from the Department of Epidemiology, Global Health Center, School of Public Health, Nanjing Medical University, led the research carried out by many universities in China, which was published in the journal Cancer Research under the American Society for Cancer Research
academician Cancer is the most important cause of death in the world, and its occurrence is the result of the combined effect of genetic and environmental factors
Zhu Meng said that previous studies have shown that more than 40% of cancer cases and deaths can be attributed to unhealthy lifestyles.
"Based on this, the team used the results of genome-wide association studies to construct PRSs for 20 cancer sites, and established the male and female CPRS by gender
In the study, the research team formed a healthy lifestyle scoring system based on the subjects’ “smoking, drinking, body mass index (BMI), physical activity, and eating habits” to evaluate healthy lifestyles among people with different genetic risks.
"We define a healthy lifestyle as not smoking or quitting smoking for more than 30 years; not drinking alcohol; BMI value of normal body shape is 18.
Studies have found that the PRS of 20 cancers are independent of each other, and almost all are related to the risk of cancer in a specific site.
Among them, compared with subjects with low genetic risk, men with moderate or high genetic risk increased overall cancer risk by 27% and 91%, respectively, while women increased by 21% and 62%, respectively
Further research has shown that genetic and lifestyle factors have a combined effect on overall cancer risk
Among the high genetic risk populations identified by CPRS, if a healthy lifestyle is adopted, the standardized 5-year cancer incidence rate for men is reduced from 7.
"The study has constructed CPRS, which can quantify the overall genetic risk of cancer, and proves that almost everyone is at high risk of cancer, and a healthy lifestyle can reduce the overall risk of cancer
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