Mov Disord-After ten years of follow-up, how does the movement, cognition and imaging of Huntington patients change?

Huntington's disease (HD) is a neurodegenerative disease caused by the autosomal dominant amplification of the cytidine-adenine (CAG) fragment in the Huntington (HTT) gene, resulting in the gradual decline of motor, cognitive and mental functions As a feature

HD was first marked by a long asymptomatic pre-stage, which lasted for decades, followed by a comprehensive manifestation of the severity of the disease

Therefore, one of the most critical obstacles to effective new clinical trials is how to assign heterogeneous individuals to homogeneous subgroups

In this way, Pubu M.

They combined the clinical and morphological imaging data of 1082 participants in the IMAGE-HD, TRACK-HD, and PREDICT-HD studies, with a longitudinal duration of 1-10 years

They found that the volume of the putamen and the caudate nucleus group can distinguish the age group of CAG, and it is the best variable that can reflect the progress

If only the volume of the caudate nucleus is used, the statistical model can best describe the advanced disease progression in the comprehensive data

The important significance of this study lies in the discovery: During the entire study process, monitoring volume changes, together with primary and secondary clinical endpoints, helps increase people’s awareness of the improvement of functional outcomes, and helps to improve clinical trials.