Mov Disord: Spinocerebellar ataxia type 3 severity is related to lifestyle

Spinocerebellar ataxia type 3 (SCA3) is the most common dominant genetic ataxia, which can lead to severe disability and premature death
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Although there is no effective treatment yet, several methods have been developed to reduce mutant proteins, and pilot trials seem to be within reach

Spinocerebellar ataxia type 3 (SCA3) is the most common dominant genetic ataxia, which can lead to severe disability and premature death

Ludger Schöls et al.

The study collected data on smoking, drinking, physical activity, physical therapy, and body mass index (BMI) of 243 SCA3 patients and 119 control groups to detect their correlation with age of onset, disease severity, and progression
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The study collected data on smoking, drinking, physical activity, physical therapy, and body mass index (BMI) of 243 SCA3 patients and 119 control groups to detect their correlation with age of onset, disease severity, and progression
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Preliminary analysis of the relationship between life>
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(A) Smoking is not significantly related to any outcome parameters

Preliminary analysis of the relationship between life>

 

Compared with the control group, SCA3 patients have less activity and drink less alcohol
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Less exercise and abstinence from alcohol are associated with more serious diseases, but not with the rate of disease progression or the age of onset

Compared with the control group, SCA3 patients have less activity and drink less alcohol

Although this study included one of the world's largest SCA3 cohorts, it lacked longitudinal progress data

SCA3 The difference in life> SCA3 patients and the control group and the correlation between life>

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