-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
In the context of the global pandemic of the new crown epidemic, the mRNA vaccine became famous
Recently, the research group of Prof.
1.
2.
2.
3.
1.
It can detect 200 bp single free DNA with ultra-high sensitivity, and realize accurate quantitative analysis of EVs internal nucleic acid, surface nucleic acid, and free nucleic acid
.
2.
The detection range covers the entire size range of exosomes (40-200nm), and the overall exosome nucleic acid loading distribution is analyzed
.
3.
Determine the type and content of EVs nucleic acid at the single particle level to determine the nucleic acid encapsulation efficiency and content
.
4.
Optimize nucleic acid loading conditions and purification methods to obtain high-quality exosomal nucleic acid drugs
.
References:
1.
Haisheng Liu etal.
Analysis of extracellular vesicle DNA at the single-vesicle level by nano-flow cytometry.
Journal of Extracellular Vesicles, 2022, e12206.
2.
Thomas C.
Roberts et al.
Advances inoligonucleotide drug delivery.
Nature reviews Drug Discovery (2020), 19, pages 673–694 3.
Kulkarni, JA et al.
“The Current Landscape of Nucleic Acid Therapeutics.
” Nature Nanotechnology, 2021, 16(841): 630-643
This study provides direct and conclusive experimental evidence for in-depth understanding of the relationship between DNA and EVs, provides theoretical experience and basis for the loading of nucleic acid in exosomes in the later stage, and is expected to promote the research and development of exosome nucleic acid drugs
1.
It can detect 200 bp single free DNA with ultra-high sensitivity, and realize accurate quantitative analysis of EVs internal nucleic acid, surface nucleic acid, and free nucleic acid
.
2.
The detection range covers the entire size range of exosomes (40-200nm), and the overall exosome nucleic acid loading distribution is analyzed
.
3.
Determine the type and content of EVs nucleic acid at the single particle level to determine the nucleic acid encapsulation efficiency and content
.
4.
Optimize nucleic acid loading conditions and purification methods to obtain high-quality exosomal nucleic acid drugs
.
References:
1.
Haisheng Liu etal.
Analysis of extracellular vesicle DNA at the single-vesicle level by nano-flow cytometry.
Journal of Extracellular Vesicles, 2022, e12206.
2.
Thomas C.
Roberts et al.
Advances inoligonucleotide drug delivery.
Nature reviews Drug Discovery (2020), 19, pages 673–694 3.
Kulkarni, JA et al.
“The Current Landscape of Nucleic Acid Therapeutics.
” Nature Nanotechnology, 2021, 16(841): 630-643
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
