Multiple articles focus on new advances in the field of dementia research by scientists!

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：National Institute On Aging

【1】bioon.

In 2017, researchers conducted research using human and animal data and found that the brain aging process caused by air pollution may increase the risk of individuals suffering from dementia.

[2] bioon.

The brain contains specialized nerve cells, called speed-sensitive cells, which change the firing speed of someone based on the speed of someone's movement.

[3] bioon.

In the article, the researchers studied 542 elderly people, using two methods to measure their aortic stiffness when they were 64 and 68 years old, and then using cognitive testing and brain magnetic resonance imaging technology ( MRI) to assess the size, connectivity, and blood supply of the participants’ different brain regions.

[4] bioon.

Physical/physical frailty (physical frailty) is a multi-system disorder of the body.

[5] bioon.
com/article/6780813.
html">JAD: Obstructive sleep apnea may be directly related to the increased risk of dementia in the population

doi: 10.
3233/JAD-200571

Recently, in a research report titled "Severe Obstructive Sleep Apnea Is Associated with Higher Brain Amyloid Burden: A Preliminary PET Imaging Study" published in the International Journal of Alzheimer's Disease, scientists from Monash University and other institutions passed the research It was found that obstructive sleep apnea (OSA, obstructive sleep apnea) may be directly related to the occurrence of high-risk dementia.

Researcher Dr.
Melinda Jackson pointed out that severe obstructive sleep apnea may increase the level of β-amyloid protein, which accumulates on the walls of the body's cerebral arteries, thereby increasing the risk of dementia.
In this study, the researchers included 34 patients who were recently diagnosed with untreated obstructive sleep apnea and 12 patients with asymptomatic sleep disorders.
They used PET brain scanning technology to analyze the brain The relationship between amyloid burden and sleep, demographic information, and emotional performance.

Image source: CC0 Public Domain

[6] bioon.
com/article/6779848.
html">Neurology: Indifferent to the lack of interest in life may make you more susceptible to dementia

doi: 10.
1212/wnl.
0000000000010951

Recently, in a research report published in the international journal Neurology, scientists from the Alzheimer's Institute and other institutions in the United Kingdom found through research that individuals who lack interest in the world around them are at increased risk of dementia.
Researchers want to analyze whether the occurrence of dementia is related to the individual’s emotional indifference (no interest).
Indifferent people often lack interest in the world/environment around them.
The manifestations of indifference include stopping participating in normal people’s activities and showing Few emotions and lack of vitality.

In this study, the researchers issued questionnaires to more than 2,000 people to assess their apathy.
At the same time, the researchers also effectively distinguished apathy from individual depression and anxiety.
They divided the volunteers into three groups: low-level apathy, moderate apathy, and severe apathy.
Then, the researchers used algorithms based on the use of dementia drugs and medical records to determine whether the participants would develop dementia and their memory and Whether there will be a significant decline in thinking ability.
The researchers followed the participants for 9 years and finally found that 381 participants may have dementia.
The researchers said that compared with participants with low levels of apathy, participants with severe apathy suffered from dementia.
At the beginning of the study, the researchers found that the population’s indifference is directly related to the decline of its memory and thinking ability, but it is not related to its rate of change over time.

[7] bioon.
com/article/6778470.
html">JAMA Netw Open: No matter how the overall amount of alcohol is consumed, drinking fragments will significantly increase the risk of dementia.

doi: 10.
1001/jamanetworkopen.
2020.
16084

Individuals suffering from alcohol use disorder are often at higher risk of dementia, and alcohol abuse is a target for successful prevention of dementia.
Alcohol can induce brain atrophy and accompanied by the loss of neurons, especially the frontal cortex of the brain; Nervous system inflammation, hypoglycemia, epilepsy, and depression are all risk factors for dementia.
In addition, the influence of alcohol on dementia may be indirect.
Diseases, such as liver and kidney disease, diabetes, high blood pressure, arrhythmia and coronary heart disease.

At present, there is research evidence that drinking alcohol as a risk factor for dementia is usually related to the overall drinking status of the individual.
However, researchers are not clear about the key role that alcohol-induced brain loss of consciousness plays in the occurrence of dementia.
Recently, an article Published in the international journal JAMA Network Open in a research report entitled "Association of Alcohol-Induced Loss of Consciousness and Overall Alcohol Consumption With Risk for Dementia", scientists from University College London and other institutions have revealed alcohol-induced consciousness through research The relationship between loss and overall drinking status and individuals suffering from dementia; in addition, the researchers also revealed whether 14 potential alcohol-related diseases mediate the association between alcohol-induced loss of consciousness and dementia events, including Diabetes, hypertension, cardiovascular disease, liver and kidney disease, etc.

[8] bioon.
com/article/6778312.
html">JAMA Neurol: Unbelievable! The number of patients dying from dementia is nearly three times as high as previously thought!

doi: 10.
1001/jamaneurol.
2020.
2831

A few days ago, scientists from Boston University School of Medicine and other institutions discovered through research that dementia may be the underlying cause of nearly three times the number of deaths in the United States than the official record.
The relevant research results were published in the international journal JAMA Neurology.

Researchers speculate that about 13.
6% of the population’s deaths are attributable to dementia, which is 2.
7 times more than the death certificate of 5.
0% of the population.
This suggests that dementia may be a potential cause of death in the population.
Understanding the cause of death is important for people.
Setting priorities and allocating resources are crucial.
Researcher Dr.
Andrew Stokes said that taking dementia as an example, it seems very challenging for us to accurately obtain the number of deaths.
This includes the lack of routine testing for dementia in the primary care system.
The results of this article show that dementia The burden of death may be higher than people realize, which highlights the importance of expanding dementia prevention and care.

[9] bioon.
com/article/6759522.
html">The Lancet latest report! Modification or improvement of 12 risk factors may prevent or slow the occurrence of 40% of dementia cases worldwide!

doi: 10.
1016/S0140-6736(20)30367-6

According to the World Alzheimer's Disease Report 2018, one person with dementia worldwide occurs every 3 seconds.
At present, there are at least 50 million dementia patients in the world, and this number is expected to reach 152 million by 2050, and about 60%-70% of dementia patients are Alzheimer's disease (AD) patients.
There are currently about 10 million Alzheimer’s disease patients in China.
It is estimated that by 2050, the number of Alzheimer’s disease patients in my country will exceed 40 million.
Nowadays, dementia has become a serious impact on the health and quality of life of the global population.
Major public health issues.

In recent years, with the decline in the mortality rate of young people, the number of elderly people including dementia has been increasing.
However, in many developed countries, the incidence of age-related dementia has begun to decline.
This may be related to the population.
Education, nutrition, health care and lifestyle changes are directly related.
Overall, more and more evidence supports the 9 potentially modifiable risk factors simulated by the Lancet Commission in 2017 for the prevention, intervention and care of dementia, including low education level and high blood pressure.
, Hearing impairment, smoking, obesity, depression, lack of physical exercise, diabetes and low social contact.
Recently, an article was published in the international journal The Lancet entitled "Dementia prevention, intervention, and care: 2020 report of the Lancet Commission" In the review report, scientists from the University College London and other institutions have added three new types of risk factors with convincing evidence to the previous nine modifiable risk factors for dementia, including excessive alcohol consumption.
, Traumatic brain injury and air pollution; now researchers have completed the latest review and meta-analysis, and incorporated these three risk factors into the updated 12 risk factors dementia prevention life cycle model.
The researchers said, In the course of an individual’s life, focusing on the above-mentioned 12 modifiable risk factors may prevent or slow the occurrence of 40% of dementia patients worldwide.
It is very important to prevent dementia, especially for low-income or middle-income countries (LMIC).
The potential for dementia prevention is also greater.

[10] bioon.
com/article/6754513.
html">A diet combination of highly processed meat + starchy food + snacks will significantly increase the risk of dementia.
A diverse diet will significantly reduce the risk!

doi: 10.
1212/WNL.
0000000000009399

A large number of studies have shown that diets rich in green leafy vegetables, nuts, whole grains, and fish can effectively reduce the risk of dementia.
Most studies focus on the impact of the amount and frequency of diet on the health of the body; however, we The food consumed and the combination of different foods may be directly related to the risk of dementia; recently, an article was published in the international journal Neurology entitled "Using network science tools to identify novel diet patterns in prodromal dementia" In the research report, scientists from the University of Bordeaux and other institutions have used a technology called "network science" to simulate the relationship between complex dietary relationships and the risk of dementia in the population, and found that, Compared with people who consume a variety of healthy foods daily, people who regularly consume foods such as highly processed meats, starchy foods (potatoes, etc.
) and snacks (biscuits, cakes, etc.
) in their daily lives suffer from The risk of dementia is higher.

Researchers speculate that the food intake of the population is a special system that can be conceptualized as a network to simulate the consumable patterns of human food items.
This network scientific method can reveal the complexity and complexity of daily eating patterns.
Non-linearity, which can help researchers reveal that compared with the control population, the common consumption pattern of food in the dementia group is often higher; in this study, the researchers recruited a total of 209 people with an average age of 78 years.
Of dementia patients and 418 non-dementia populations matching the former in age, gender, and education level; during the 12-year follow-up, the researchers determined dementia based on the participants’ baseline food frequency questionnaire For each case, they randomly selected two control individuals from the group at risk of the age at which the case was diagnosed, and matched them with the age, gender, education, and season of the survey at the time of dietary assessment.
The researchers used interactive information (A measure that can detect non-linear relationships) inferred the food network of the participants in the study group and the control group, and compared the differences in food intake patterns between the two groups.
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