Mutations in the SLC26A3 gene affect the mechanisms of IBD risk

(1) In the DSS-induced colitis mouse model, the colon permeability of DRA knockout mice increased significantly, and the level of ZO-1, closed protein, E-calcium adhesive protein, etc. was significantlyreduced; (2) A decrease in the expression of closed protein and E-calcium mucoprotein can also be observed in the colon organs of DRA knockout mice and in the Caco-2 cell line where shRNA knocks down DRA;(3) DRA knockout intestinal bacteribus disorders in mice regulate the expression of tightly connected proteins;(4) mechanism, in the colon of DRA knockout mice, RNA binding protein - CUGBP1 and closed protein and E-calcium adhesive protein mRNA binding increased to inhibit the expression of the latest two.editor-in-chief's recommendation SLC26A3-coded DRA is a key intestinal chlorine ion transporter protein that was recently found to be a new susceptible gene for IBD, but the mechanism behind it is not yet clear. A new study published in Gastroenterology found that in the colon of DRA knockout mice, the binding of the RNA-binding protein CUGBP1 to the mRNA of the tightly connected protein increased the expression of the close-linked protein significantly, thereby increasing colon permeability to increase the susceptivity of mice to DSS-induced colitis, and that DRA knock-out of the mediated intestinal bacteriology also played a partial regulatory role.
。