My scientists reveal the regulatory networks and markers of the heartbeat "hub"

Recently, Withji University Chen Yihan academician, Professor Xue Zhigang co-research, with the help of pacing cell separation technology, single-cell transcription group sequencing and analysis technology, cytoimaging technology, gene modification technology, cell-induced differentiation technology and a series of electrophysiological technology, from the single-cell resolution level to analyze the core gene regulation network of sinus room pacing cells, and found the potentially important biomarkers of sinus room pacing cells.
results were published online in the latest issue of the international authoritative journal Nature Communications.
a number of questions that plague sinus cell biology and medical research, such as: What kind of molecular cell system does sinus cell cells have? Does the sinus room pacing cells really have an advantage in excited "dominant clusters"? What is the core gene regulation network that controls the function of sinus cells? What are the biomarkers specific to sinus cells? The team revealed cluster types and molecular systems of sinus-building pacing cells in three species, from rats to rabbits to monkeys.
they used information technology and functional verification to initially prove that the sinus cells of different species contained a "dominant cluster" that controlled heart beats.
and they found that the cells in these clusters were scattered in different areas of the sinus complex, a distribution that may be beneficial to the steady-state maintenance of the heartbeat.
they identified a core gene regulatory network that controls heart beats, and individual molecules in the network have been shown by their experiments to significantly regulate the frequency of heartbeats.
they show that some transcription factors are also in the network.
they also found biomarkers of sinus cells, suggesting that Vsnl1 may be a biomarker that can be used to identify pacing cells and explore arrhythmic disorders.
the above findings provide basic data for the study of sinus knots and contribute to the in-depth exploration of sinus knot biology, pathology and therapeutics.