Nanjing University: Targeting the SHP2-DOK1-uridine axis can be used as a new strategy to improve osteoarthritis

Osteoarthritis (OA) is one of the most common disabling joint diseases

In recent years, more and more new cartilage protection strategies have been proposed

Protein tyrosine kinase (PTK) regulates the occurrence and development of OA by activating a series of signal transduction pathways

Based on the above background, the researchers first compared the expression distribution of 107 PTP genes in the human OA cartilage single-cell sequencing data published by Peking University’s Tang Fuchou team.

The researchers further used 10×TMT-based whole proteomics and SILAC/SH2 domain supramolecular-based tyrosine phosphoproteomics to explore the mechanism

In summary, this study revealed the molecular mechanism of SHP2 mediating the imbalance of cartilage homeostasis.

This achievement is in the form of a long article titled SHP2 inhibition attenuates osteoarthritis by maintaining homeostasis of cartilage metabolism via the DOK1/UPP1/uridine cascade on September 27, 2021, in the official publication of the American Academy of Rheumatology Arthritis & Rheumatology (District 1, IF: 10.