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The mechanical forces produced by cells are thought to affect the function of cells and organs and are also associated with some human diseases.
researchers tried to detect cellular forces by feeding worms special nanoparticles, according to a press release from Stanford University in the United States.
this interdisciplinary study could help shed light on how cellular forces play a role in the human body.
the researchers' ultimate goal is to detect the mechanical forces produced by human cells.
first tested cellular force detection techniques on transparent, beautiful crypto-worms.
this is because, like in the human body, the digestion process in the body of the beautiful cryptobacteria also requires mechanical grinding and displacement, and researchers can observe how nanoparticles reflect cellular strength during digestion.
In the process of digesting nanoparticles, which the researchers exposed to near-infrared lasers, the nanoparticles change the color of the glow as the pressure around them changes, so they can display real-time information about the cellular force they are experiencing.
when the mechanical force changes from the nano-Newton magnitude to the micro-Newton magnitude, the glowing color of each nanoparticle changes from red to orange accordingly.
Dion, who led the study, says cellular mechanics play an important role in the fate and function of cells or organs, such as beating the heart, hearing sounds in the ears, or wound healing.
changes in cell strength can affect many diseases, such as heart disease and cancer, nanoscale cell force data can be used for early detection of disease.
use tiny nanoparticles to detect cellular forces, meaning researchers can map high-definition attempts to reflect the thrust and pull generated between cells.
In the future, if such biocompulsant nanoparticles are injected into a particular part of the body, such as a wound or tumor, the laboratory can map the subtle activity of cells around a particular site by reading data on the color changes of the nanoparticles.
in addition to studying healthy beautiful reclusive rodworms, they will also introduce genetic mutations of the beautiful recessive rod worms to conduct research to analyze the effects of gene expression on cellular strength.
will help researchers better understand the formation of diseases related to the digestive system and hernia.
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