Nat Cancer: Relationship between brain cancer and tissue repair

"Our data suggest that the correct mutations in specific cells in the brain can change due to damage, causing tumors," said Dr. Peter Dix, a senior scientist and head of the dream team.
results were published in the journal Nature Cancer.
these findings may provide new treatments for patients with glioblastoma.
: "Glioblastoma can be thought of as a wound that never stops healing.
we are pleased that this tells us how cancer originates and grows and opens up new ideas for treatment by focusing on injury and inflammatory responses.
" researchers used the latest single-cell RNA sequencing and machine learning techniques to map the molecular composition of glioblastoma stem cells (GSCs), which Dirks' team has previously shown can cause tumors to develop and relapse after treatment.
they found new GSC subsumes that have molecular markers of inflammation and are mixed with other cancer stem cells in the patient's tumor.
This suggests that some glioblastomas begin to form during normal tissue healing, a process that produces new cells to replace cells lost to injury, derails due to mutations, and may even disappear many years before the patient develops symptoms.
the study, once mutant cells are involved in wound healing, they cannot stop multiplying because normal controls are disrupted, stimulating tumor growth.
s goal is to identify a drug that can kill glioblastoma stem cells," he said.
we first need to understand the molecular properties of these cells so that we can target them more effectively.
" Source: Brain cancer linked to tissue healing Original source: Gradient of Developmental and Injury Responses transcriptional states defines functionality afterpinning glioblastoma heterogeneity, Nature Cancer (2021). DOI: 10.1038/s43018-020-00154-9 ,