Nat Com: Improving the body's own immunity can fight cancer

Immunotherapy is not the use of chemicals or radiation, but a cancer treatment that helps the patient's immune system fight cancer.

Immunotherapy is not the use of chemicals or radiation, but a cancer treatment that helps the patient's immune system fight cancer.

Although the use of immunotherapy in the blood or blood organs to treat certain types of cancer has been successful, in solid tumors, the work of T cells is much more difficult.

Published in Nature Communications recently , researchers are committed to engineering T cells and formulating engineering design standards to mechanically optimize these cells or make them more " fit " to overcome these obstacles.

In order to further develop design criteria for enhancing T cell migration in tumors , it is important to first understand the state that leads to more robust T cell movement.

In order to further develop design criteria for enhancing T cell migration in tumors , it is important to first understand the state that leads to more robust T cell movement.

In order to engineer cytotoxic T cells, the authors used advanced gene editing technology ( also known as genome editing ) to change the DNA of T cells so that they could better overcome tumor barriers.

Mechanisms and microtubules regulate the interaction of T cells with tumor-related nanostructures

Mechanical and microtubule regulating T cell interactions nanostructures tumor-associated mechanical adjustment and microtubule mechanical adjustment and microtubule T T interaction nanostructures tumor cells associated with cell nanostructures tumor-associated interaction

 Cell migration behavior, using reasonable engineering design methods, combining genome and cell engineering, changing natural cytotoxic T cells and ( or ) further enhancing engineered T cells, so that they can most effectively pass and sample the entire tumor volume, which can improve the solidity The effect of tumor treatment has even further improved cell-based tumor treatment methods.

 Cell migration behavior, using reasonable engineering design methods, combining genome and cell engineering, changing natural cytotoxic T cells and ( or ) further enhancing engineered T cells, so that they can most effectively pass and sample the entire tumor volume, which can improve the solidity The effect of tumor treatment has even further improved cell-based tumor treatment methods.

In order to determine the effect of stiffness on directional T cell migration, the researchers analyzed the directionality of the unit relative to nanophotography ( ie contact guidance ) and the migration speed on the substrate.

By tracking the movement of cells over time, it was found that there are significant differences in T cell contact guidance under soft and rigid conditions .

The microtubule contraction axis regulates T cell mechanics and migration in a three-dimensional environment

Microtubule contraction axis adjustment in a three-dimensional environment T cell migration and mechanical microtubule contraction axis adjustment in a three-dimensional environment microtubule contraction axis adjustment in a three-dimensional environment T T cell migration and mechanical cell migration and Mechanics

 In the three-dimensional environment and living tumors, researchers found that microtubule instability leads to increased Rho pathway-dependent cortical contraction and promotes migration, while the clinically used microtubule stabilization chemotherapy greatly reduces effective migration.

 In the three-dimensional environment and living tumors, the researchers found that microtubule instability leads to the increase of Rho Rho pathway-dependent cortical contraction, which promotes migration, while the clinically used microtubule stabilization chemotherapy greatly reduces effective migration.

Studies have shown that, both from a pharmaceutical point of view or by genomic engineering, rational manipulation microtubules whether or by genomic engineering, reasonably manipulated from a pharmaceutical perspective of microtubule - - contraction axis, can make engineering contraction axis, can make engineering T T cells more efficiently pass and interrogate the three-dimensional stroma and tumor volume.

Therefore, engineered cells that better navigate through the three-dimensional microenvironment may be part of an effective strategy to improve the effectiveness of immunotherapy.

Using cell engineering methods to fight cancer is a relatively new field.

Literature reference: Erdem D.
Tabdanov, Nelson J.
Rodríguez-Merced, Alexander X.
Cartagena-Rivera, Vikram V.
Puram, Mackenzie K.
Callaway, Ethan A.
Ensminger, Emily J.
Pomeroy, Kenta Yamamoto, Walker S.
Lahr, Beau R.
Webber, Branden S.
Moriarity, Alexander S.
Zhovmer, Paolo P.
Provenzano.
  Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments .
  Nature Communications Nature Communications , 2021; 12 (1) DOI:  10.
1038/s41467-021-22985-5 10.
1038/s41467-021-22985-5 10.
1038/s41467-021-22985-5

 

 

 

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