Nat Commun: CNS Tumor Immunology Microeconviral Analysis Reveals Anti-Tumor Immunity Correlation.

Immunotherapy is an attractive alternative cancer strategy compared to traditional surgery, chemotherapy and radiotherapy, and is particularly suitable for targeting diffuse invasive growth tumors such as central nervous system (CNS) tumors.
of tumor immune micro-environment (TIME) is a key determinant of tumor-immune interaction.
, in order to take full advantage of the potential of immunotherapy and/or targeted drug combinations, specific ?? TIME tailors the treatment.
the study analyzed the tumor immune micro-environment of 6,000 children's CNS tumors using methylCIBERSORT.
researchers defined 11 types of non-cancer cells to assess their relative immersion ratio in 80 CNS tumor subsypes.
Based on the results, the researchers divided 80 CNS tumor subtypes into three broader clusters of immune clusters associated with the CNS tumor subtype: myeloma (n=2325), malignant transverse fibroids (n=229) and high-level gliomas (n=401) in children.
the three queues, the researchers found significant correlations between molecular subtypes, mutations, and patient prognostics.
researchers further identified tumor-specific clusters associated with the immunotherapy response.
, the study provides a basis for future immunotherapy and prognostication by conducting immunospectral analysis in children with CNS tumors.
Grabovska, Y., Mackay, A., O'Hare, P. et al. Pediatric pan-central nervous system system tumor analysiss of immune-cell in-regulations correlates of antitumor immunity. Nat Commun 11, 4324 (28 August 2020). QQY Source: MedSci Original !-- Content Presentation Ends -- !-- To Determine If Login Ends.