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Mitochondria are responsible for synthesizing most of the ATP needed for cell function.
Mitochondrial diseases refer to genetic defects that affect OXPHOS by destroying RC or ATP synthase complexes, or by affecting mitochondrial DNA (mtDNA) replication/transcription/translation, RC cofactor biosynthesis and mitochondrial biogenesis.
The defects of Complex III are related to a highly variable clinical pedigree.
Pyocyanin, an oxidoreductase from bacteria, can replace the redox function of complex III and play the role of electronic shunting.
Pyocyanin increases mitochondrial function in patients' cells
Pyocyanin increases mitochondrial function of patients' cells Pyocyanin increases mitochondrial function of patients' cellsIn addition, pyocyanin normalizes the mitochondrial membrane potential and slightly increases the production and biological production of ROS.
Low concentration of pyocyanin can significantly improve the body's exercise ability.
Daily administration, continuous administration of pyocyanin for two months is not toxic to control mice.
Original source:
Original source:Roberta Peruzzo et al.
Roberta Peruzzo et al.
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