Nat Commun: RFC4/Notch1 positive feedback loop can promote the metastasis and stem cell characteristics of non-small cell lung cancer

Lung cancer, as the most common type of cancer, is also the leading cause of cancer-related deaths worldwide

It is estimated that nearly two-thirds of NSCLC patients show local or distant metastasis of the disease at the time of diagnosis , and only about 15% of patients with metastatic NSCLC can survive 5 years or more after metastasis

Therefore, understanding the causes of clinical difficulties of the disease and identifying effective therapeutic targets or prognostic biomarkers is very important for the early identification of metastatic NSCLC

RFC4 is essential in Notch activation-induced NSCLC metastasis and stemness

In addition, RFC4 is a functional transcription target gene of the Notch1 signal transduction pathway, and high expression levels of RFC4 and NICD1 will continue to form a positive feedback loop and continue to activate the Notch signal pathway, which will not only induce the tumorigenicity and tumorigenicity of NSCLC.

RFC4 is amplified in NSCLC and is related to the occurrence and development of NSCLC

In summary, the results of this study show that the positive feedback loop between RFC4 and NICD1 plays a key role in the metastasis and stem cell characteristics of NSCLC, and reveals its diagnostic and prognostic potential in the treatment of NSCLC