Nat Commun: Scientists have discovered a new molecular mechanism of reduced blood vessels in the brains of patients with Alzheimer's disease

June 3, 2021---Human Alzheimer's disease (AD) brain accumulates angiogenesis markers, but contradicting this, the brain microvessels around Aβ plaques are decreasing; recently, a The article was published in a research report entitled "Non-productive angiogenesis disassembles Aβ plaque-associated blood vessels" in the international journal Nature Communications .

Nature Communications scientists from the University of Seville and other institutions in Spain have discovered through research that a new mechanism in Alzheimer’s disease may cause vascular disturbances around amyloid plaques, which is the disease.

Image source: https://’s disease is the main cause of dementia in the global population.

The results of this study show that Alzheimer’s disease can induce abnormalities in angiogenesis, thereby promoting the loss of blood vessels rather than the formation of new blood vessels, which will undoubtedly aggravate the pathological manifestations of the disease; by identifying the molecular pathways involved, researchers have Reasonable design of new therapeutic strategies that can effectively slow down the effects of the disease; the research data in this article also links familial/hereditary Alzheimer’s disease with the formation of new blood vessels, thus highlighting the importance of vascular components in the disease Sex.

Alzheimer’s disease can induce abnormalities in angiogenesis, thereby promoting the loss of blood vessels instead of forming new blood vessels, which will undoubtedly aggravate the pathological manifestations of the disease; by identifying the molecular pathways involved, researchers can rationally design energy A new type of therapeutic strategy that effectively slows down the effects of the disease; the research data in this article also links familial/hereditary Alzheimer's disease with the formation of new blood vessels, thus highlighting the importance of the vascular components in the disease.

In AD mouse models, angiogenesis is concentrated around Aβ plaques.

Image source: Alvarez-Vergara, et al.

Nat Commun

One of the main characteristics of patients with Alzheimer’s disease is the accumulation of highly toxic substances in the brain, that is, the accumulation of senile plaques or senile plaques.

The brain consumes the body's oxygen and nutrients, so the local reduction of these substances supplied through the blood may represent an additional pressure that exceeds the existing pressure of the accumulation of toxic substances.

In this study, the researchers confirmed that NPA (non-productive angiogenesis) and microglia play a key role in the process of local vascular breakdown, and also emphasized that the body of Alzheimer’s disease patients Premature loss of vascular tissue function

Original source:

Original source:

Alvarez-Vergara, MI, Rosales-Nieves, AE, March-Diaz, R.

Alvarez-Vergara, MI, Rosales-Nieves, AE, March-Diaz, R.
et al.
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels.
Nat Commun 12, 3098 (2021).
doi: 10.
1038/s41467-021- 23337-z Non-productive angiogenesis disassembles Aß plaque-associated blood vessels.
Nat Commun