Nat Commun: What are the risk genes for skin cancer?

Cancer screening and early diagnosis are considered key public health strategies to reduce the burden of cancer.
year, more than 14 million people worldwide are diagnosed with cancer, and 8.8 million people die from cancer, accounting for one-sixth of all deaths worldwide.
estimated that 50-60% of cancers can be prevented or successfully treated through effective cancer prevention and early detection programmes.
skin cancer is the most commonly diagnosed cancer, and it is one of the most preventable forms of cancer.
in the United States, one in five Americans is likely to develop skin cancer in their lifetime.
Even melanoma, the three main forms of skin cancer (including melanoma, substrate cell carcinoma (BCC) and squamous cell carcinoma (SCC) are more aggressive, with a five-year survival rate of 98% if diagnosed at an early stage.
preventable, more than 15,000 Americans die each year from skin cancer.
Recently, researchers trained and validated three main types of skin cancer -- substrate cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma risk prediction models -- on a cross-sectional and longitudinal data set of 210,000 volunteers who answered an online survey covering personal and family skin cancer histories, skin susceptibility, and UV exposure.
developed a major disease risk score (DRS) that combined all 32 identified genetic and non-genetic risk factors.
the highest percentage of DRS increases the risk of skin cancer by up to 13 times (more than 2.5 percent per standard deviation) compared to the middle DRS percentage.
to track the lifetime risk of three types of skin cancer, the researchers also developed a second age-independent disease score, called DRSA.
by using incident cases, the researchers demonstrated that DRSA could be used in early detection programs to identify high-risk gradient individuals and predict when they might develop skin cancer.
DRSA high score is associated not only with early diagnosis of the disease (up to 14 years), but also with more severe and relapsed skin cancer.