Nat Commun Ye Xiaojing/Lin Weijie/Zhang Yan reveal the important role of meningeal lymphatic vessels in the regulation of sex differences in stress susceptibility

Depression is one of the most common mental disorders, affecting approximately 4.

Recent studies suggest that neuro-immune interactions may mediate an individual's susceptibility to stress

Using a 6-day sub-chronic variable stress (SCVS) model, the researchers found that SCVS induced depression-like and anxiety-like behaviors in female but not male mice, accompanied by female but not male mice.

In order to explore the mechanism of meningeal lymphatic vessel function in regulating individual's susceptibility to stress, the researchers injected cerebrospinal fluid circulating tracer into the cisterna magna and found that the distribution of the tracer in the brain parenchyma was not uniform, but enriched Brain regions related to emotion regulation include the prefrontal cortex (mPFC) and the ventral tegmental nucleus (VTA)

In order to analyze the mechanism of stress-induced damage to meningeal lymphatic vessels, the researchers first detected the levels of the stress hormone corticosterone in the peripheral blood of male and female mice before and after stress

This study finds for the first time that meningeal lymphatic vessel damage caused by repeated stress may be a key factor affecting the susceptibility of individuals of different genders to stress, suggesting that detecting changes in meningeal lymphatic vessels by imaging may be used as an early clinical detection and diagnosis of stress-related mental disorders.

Doctoral student Dai Weiping, master student Yang Mengqian, and doctoral student Xia Pei are the co-first authors of the paper

The research of Professor Ye Xiaojing and Professor Lin Weijie's team focuses on: (1) neural circuits, neural coding and molecular mechanisms of memory, and the intervention mechanism of cognitive impairment; (2) brain-immune interaction in neuropsychiatric diseases such as depression and anxiety The mechanism of action in development, and has published many articles in Nature Neuroscience, Nature Communications, Molecular Neurodegeneration, PNAS, Autophagy and other journals as the corresponding author and first author (including co-authors), and won the National Science and Technology Innovation 2030-Brain Science and Supported by major projects of brain-like research, general projects of the National Natural Science Foundation of China, and key projects of Guangzhou Science and Technology Bureau

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