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Nat Med: Inherited PD-1 deletion can cause tuberculosis and autoimmune diseases

 Last Update: 2021-07-29
 Source: Internet
 Author: User

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It is estimated that about 25% of the world’s population is infected with Mycobacterium tuberculosis (Mtb), but only 5-10% of those infected eventually develop tuberculosis (TB)

Approximately 25% of the global population is infected with Mycobacterium tuberculosis (Mtb), but only 5-10% of those infected eventually develop tuberculosis (TB)

Previous studies have shown that two rare single-gene inborn immunodeficiency (IEI) are the basis of multiple TB families: autosomal recessive (AR) IL-12Rβ1 and TYK2 deletions

immunity

Although autoimmunity is another major social public health burden

After programmed cell death protein 1 (PD-1) blockade, adverse events including TB and autoimmune diseases will occur, but the related molecular mechanisms are still unclear

Children with inherited PD-1 deficiency suffer from tuberculosis and autoimmune diseases

Hereditary PD-1 deficiency of children suffering from tuberculosis and autoimmune diseases of children

The researchers found that the patient's lymphocytes produced only a small amount of IFN-γ under the stimulation of mycobacteria, which was similar to those of patients with congenital IFN-γ deficiency who were prone to tuberculosis

PD-1 expression and function analysis

All in all, the results of the study revealed the indispensable role of PD-1 in regulating anti-mycobacterial immunity and self-tolerance, and identified potential molecular targets for the diagnosis and treatment of tuberculosis patients and PD-1 blockade patients.

The results of this study reveal the indispensable role of PD-1 in regulating anti-mycobacterial immunity and self-tolerance, and identify potential molecular targets for the diagnosis and treatment of tuberculosis patients and PD-1 blocking patients’ autoimmunity Response

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.

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