Nat neuroscience: AHR is the host factor of the Zika virus and a candidate for antiviral therapy.

The !---- to identify host factors in the ZIKV replication process can guide effective therapeutic interventionsIn genome-wide transcription studies, the authors found that ZIKV infection triggered the activation of aromatic hydrocarbon receptors (AHR)In particular, ZIKV infection induces the production of Kynurenine (Kyn), activates AHR, and limits the production of type I interferon (IFN-I) involved in antiviral immunityIndividuals in the population showed varying degrees of susceptibility to the pathology caused by viral infection and virus, but the mechanism is not clearEnvironmental factors, such as contaminants, diet, and the microbiome, affect the processes and clinical outcomes of multiple viral infections, including ZIKVAHR agonists are produced not only by host metabolism, but also by environmental pollutants, diets and symbiotic floraMethods: In order to determine the molecular mechanism of ZIKV replication, RNA-sequence analysis (RNA-seq) messenger RNA expression in human liver-derived HepG 2 cells infected with ZIKV179 differential expression genes associated with cellular processes were detectedThe effect of ZIKV infection on signal transduction was detected by transcription factor AHRThe validity of these observations was further verified by analyzing rna-seq data in the public database, which detected an upturned aHR signal in the brain organs of a person infected with zIKVRESULTS: AHR is a ZIKV host factor that interferes with ifN-I-driven and PML protein dependence antiviral immunityThese findings identified AHR as a candidate treatment target for ZIKV and other yellow virusesOriginal origins: Giovannoni, F., Bosch, I., Polonio, C.Met alAHR is a Zika virus host factor and a candidate target for antiviral therapyNat Neurosci (2020)MedSci Original Source: MedSci Original !-- Content Presentation Ends - !-- Determine Stocing End s--