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Nat Rev Clin Oncol: Cancer-related accelerated aging and biological behavior modifiers: a framework for research and clinical treatment

 Last Update: 2022-01-08
 Source: Internet
 Author: User

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There is increasing evidence that cancer patients receiving cytotoxic treatments (such as chemotherapy or radiotherapy) have an increased risk of accelerated physical and cognitive aging
.

In addition, accelerated biological aging is suspected to be the driving force behind many of the observed effects

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Key points:

Cancer and its treatment are believed to accelerate biological aging, leading to poor cognitive, behavioral, and functional outcomes for cancer survivors
.

Cancer and its treatment are believed to accelerate biological aging, leading to poor cognitive, behavioral, and functional outcomes for cancer survivors

Modifiable host-specific factors are known to affect the aging biology of non-cancer individuals, including psychosocial stress, lack of sleep, lack of physical activity, obesity, and tobacco and alcohol use

Behavioral intervention and/or modification of these host factors may directly change the biological aging process of cancer patients and cancer survivors, thereby improving health and longevity

We recommend that these host factors be considered in cancer-related age acceleration models, and interventions aimed at reducing stress, improving sleep health, increasing physical activity, controlling weight, and/or reducing alcohol and tobacco use as promising solutions Method of research

In summary, this review outlines the growing literature linking cancer and its treatments to accelerated physical, cognitive, and biological aging, and expands the model to include several important behavioral modifiers that may improve these aging patterns
.

Key behaviors known to affect the aging biology of non-cancer individuals include perception of stress, sleep disorders and insomnia, sedentary life>

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