"Natural enemy" of HFMD virus in medicinal plants

Enterovirus 71 (EV71) is the main pathogen of HFMD Chinese scientists have recently discovered that traditional medicinal plants contain "natural enemies" that strongly inhibit HFMD virus, which provides a leading compound for the development of anti EV71 drugs The research was carried out by Guangzhou Institute of biomedicine and health, Chinese Academy of Sciences, in cooperation with Kunming Institute of Botany, Chinese Academy of Sciences The relevant research results were published online in the European Journal of Pharmaceutical Sciences Enterovirus 71 (EV71) is the main pathogen of HFMD At present, there is no effective drug for EV71 Peng Tao, a researcher of Guangzhou Institute of biomedicine and health, who has long studied the mechanism of virus infection and pathogenesis, developed drugs and diagnostic methods, and Luo Xiaodong, a researcher of Kunming Institute of Botany, who has long been engaged in the development of active ingredients and new drugs of ethnic medicinal plants, recently screened the antiviral active substances of extracts of traditional medicinal plants from the leaves of traditional medicinal plants Two compounds were extracted: chrysosplenetin and penduletin Through the inhibition of cytopathic effect test, plaque reduction test and virus production inhibition test, the researchers have proved that these two compounds have strong inhibitory activity on enterovirus 71 (EV71), and can effectively inhibit the synthesis of virus RNA Surprisingly, further studies have shown that both compounds exhibit similar inhibitory activities against a variety of human enteroviruses.