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Nature: A new breakthrough in the traceability of the new crown, the discovery of a bat coronavirus that can infect human cells through ACE2

 Last Update: 2022-03-03
 Source: Internet
 Author: User

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It has been more than 2 years since the new crown epidemic pandemic has caused hundreds of millions of infections and hundreds of deaths around the world

On February 16, 2022, Marc Eloit and others of the Pasteur Institute in France published a research paper entitled: Bat coronaviruses related to SARS-CoV-2 and infectious for human cells in the journal Nature

Marc Eloit Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

The research team found a coronavirus with a genome similar to the new coronavirus in bats in a karst limestone cave in northern Laos, and the coronavirus can infect human cells

Prior to this, a variety of SARS-CoV-2-related coronaviruses have been found in Asian horseshoe bats.

A variety of SARS-CoV-2-related coronaviruses have been found in Asian horseshoe bats.

The research team examined 645 bats (46 species of bats belonging to 6 families) living in limestone caves in northern Laos and found 3 coronaviruses closely related to SARS-CoV-2.

More importantly, compared with the SARS-CoV-2 strains isolated at the beginning of the COVID-19 outbreak, these newly discovered coronaviruses bind the human ACE2 protein more efficiently, and can enter human cells by recognizing ACE2 and release them in cells.

Compared with the SARS-CoV-2 strains isolated at the beginning of the COVID-19 outbreak, these newly discovered coronaviruses bind the human ACE2 protein more efficiently and can enter and replicate in human cells by recognizing ACE2.

Overall, this study identified new bat coronaviruses in limestone caves in the back of Laos, which are related to the new coronavirus (SARS-CoV-2) and are able to enter human cells through human ACE2 and in human cells replicate and therefore have the potential to infect humans

Original source:

Temmam, S.

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

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