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This article is original by the Translational Medicine Network.
Please indicate the source for reprinting.
Author: Daisy Guide: Recently, a study published in "Nature" shows that scientists have detected at least three in free-range white-tailed deer in six places in northeastern Ohio.
A mutant strain of the new coronavirus
.
The fact that wild deer may be infected reminds people that a new maintenance host may have been established outside of humans
.
Will this complicate future COVID-19 mitigation and control plans? Because white-tailed deer as the virus host of SARS-CoV-2 may cause one of two results: the virus may mutate in the white-tailed deer, which may promote the spread of new mutant strains to other species (including humans); or the virus can Survive in the unmutated white-tailed deer, while it continues to evolve in humans, and at some point when humans have no immunity to the deer-infected strain, these variants may be transmitted to humans
.
There is an urgent need to establish a comprehensive "One Health" plan to monitor deer, the environment and other wild animal hosts around the world
.
The research team reported that scientists have detected at least three variants of the new coronavirus in free-range white-tailed deer in six locations in northeastern Ohio
.
Earlier, a news report published on the website of "Nature" magazine stated that US Department of Agriculture researchers conducted a new coronavirus antibody analysis study on the serum samples of some white-tailed deer in the states of Michigan, Illinois, New York and Pennsylvania and found that 1/3 The white-tailed deer sampled contained antibodies related to the new coronavirus.
Among them, 60% of the samples collected in Michigan had antibodies detected
.
According to a magazine, it is likely that after the deer herd was infected with the virus, the immune system resisted the infection and developed antibodies
.
This new study was published in the journal Nature on December 23 and published an article entitled "SARS-CoV-2 infection in free-ranging white-tailed deer"
.
The first report of white-tailed deer active COVID-19 infection supported by the growth of virus isolates in the laboratory was detailed, indicating that researchers have recovered live samples of the SARS-CoV-2 virus, not just its genetic traces
.
(The researchers provided an unedited version of this manuscript in order to obtain its findings as soon as possible.
) Based on the genome sequencing of samples collected between January and March 2021, the researchers determined that the variant that infected the wild deer was similar to that in Ohio at the time.
The SARS-CoV-2 virus strain that is prevalent in COVID-19 patients in the state matches
.
The sample collection occurred before the Delta variant spread widely, and the variant was not detected in these deer
.
The team is testing more samples to examine new variants as well as earlier variants.
The continued existence of these variants indicates that the virus can establish and survive in this species
.
Andrew Bowman, associate professor of veterinary preventive medicine at Ohio State University and the senior author of the paper, said that the fact that wild deer may be infected "makes people think that a new maintenance host may have been established outside of humans
.
"
Bowman said: "According to evidence from other studies, we know that they are exposed in the wild, we can infect them in the laboratory, and the virus can spread between deer
.
Here, we are talking about in the wild, they are infected
.
If They can maintain this virus, and we have a new potential source of SARS-CoV-2 to infect humans
.
This means that in addition to tracking people’s conditions, we also need to know what’s in the deer’s body
.
"This may complicate future COVID-19 mitigation and control plans
.
"There are still many unknowns: how the deer were infected, whether they can infect humans and other species, how the virus manifests in animals, and whether it is a short-term or long-term infection
.
The
research team collected 9 northeastern Ohio 360 white-tailed deer in the area nasal swabs
.
using PCR detection methods, the scientists detected in 129 (35.
8%) of the deer samples of genetic material to at least three different virus strains
.
deer six
.
The
analysis shows that in the first few months of 2021, the B.
1.
2 virus that dominates Ohio has spread to deer in different locations several times group
.
observed B.
1.
2, B.
1.
582 and B.
1.
596 virus may spread between deer and deer, so that the obtained virus spike protein (comprising the receptor binding domain) and the ORF1 amino acid substitutions, in which It is not common in humans
.
Bowman said: "Based on research results, it is shown that humans gave it to deer, and we gave it to them many times
.
We have evidence that six different viruses were introduced in these deer herds, and it was not that a single population was infected once and then spread
.
"Each site was sampled one to three times, for a total of 18 sample collection dates
.
According to the results of the study, the researchers estimated that the infection rate of these 9 sites ranged from 13.
5% to 70%, among which the infection rate in the four densely populated communities Location, the highest observed prevalence rate
.
Bowman said that white-tailed deer as a SARS-CoV-2 virus host may cause one of two results: the virus may mutate in the white-tailed deer, which may promote the spread of new mutant strains to other species (including humans); or The virus can survive in unmuted white-tailed deer, while it continues to evolve in humans, and at some point when humans have no immunity to strains that infect deer, these variants may spread to humans
.
How transmission occurred in these white-tailed deer in the first place, and how transmission occurred between species are open questions related to these discoveries
.
If these white-tailed deer have the same source of infection, other animals may also be exposed to this source of infection
.
The research team speculates that a variety of activities may allow white-tailed deer to come into contact with humans (and be infected with the new crown virus), including captive deer, field research, wildlife tourism, feeding and hunting
.
White-tailed deer may also be infected through environmental means—perhaps by drinking water contaminated by humans
.
Or contact with other infected species
.
Studies have shown that the new coronavirus can be transmitted through human feces and can be detected in wastewater
.
According to the official website of the "National Deer Association" of the United States, due to the impact of the new crown virus, in the autumn of 2020, Maryland and West Virginia have completely stopped sampling and testing for "chronic wasting diseases" that kill deer
.
This is the first time sampling and testing work has been stopped since the "chronic wasting disease" was first discovered in a herd of deer in Maryland in 2010
.
A spokesperson for the Maryland Department of Natural Resources said: “This is to prevent the spread of the new crown virus and protect the safety of workers and the public
.
” The white-tailed deer tested in this study are part of a population control plan, so they do not constitute Spread threat
.
Although it is estimated that there are 600,000 white-tailed deer in Ohio and about 30 million in the United States, Bowman said that this sample survey is concentrated in densely populated areas and does not represent all free-range deer
.
Reference materials: https://medicalxpress.
com/news/2021-12-covid-infection-deer-ohio.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity [Live Preview] New CRISPR technology combined with high-efficiency electrotransformation technology to help gene editing experience sharing, action knowledge practitioners-Single-cell Scientific Research Creation Camp (Wuhan Station) Popular·Article Basic Research [Science Sub-Journal] Transforming Artificial Lung-Lizard Provides an amazing method! Intestinal flora [Nature] Did you take hypoglycemic drugs ineffective? Because the intestinal microflora is in the process of cancer treatment [PNAS] Chinese medicinal materials thyme and oregano have found anti-cancer compounds for disease diagnosis and treatment [Nature Sub-Journal] This is another step towards changing the US$70 billion global diagnostic industry! Protein biosensors can measure toxic drugs for cardiovascular disease in cancer, arthritis, and organ transplant patients [JAMA Sub-Journal] Are you stressed? Stress increases the risk of cardiovascular disease! Scientific research [Cell Sub-Journal] Why do pain and anxiety speed up the breathing rate? The scientific research "Science" announced the breakthrough of 2021: A problem that has troubled biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!
Please indicate the source for reprinting.
Author: Daisy Guide: Recently, a study published in "Nature" shows that scientists have detected at least three in free-range white-tailed deer in six places in northeastern Ohio.
A mutant strain of the new coronavirus
.
The fact that wild deer may be infected reminds people that a new maintenance host may have been established outside of humans
.
Will this complicate future COVID-19 mitigation and control plans? Because white-tailed deer as the virus host of SARS-CoV-2 may cause one of two results: the virus may mutate in the white-tailed deer, which may promote the spread of new mutant strains to other species (including humans); or the virus can Survive in the unmutated white-tailed deer, while it continues to evolve in humans, and at some point when humans have no immunity to the deer-infected strain, these variants may be transmitted to humans
.
There is an urgent need to establish a comprehensive "One Health" plan to monitor deer, the environment and other wild animal hosts around the world
.
The research team reported that scientists have detected at least three variants of the new coronavirus in free-range white-tailed deer in six locations in northeastern Ohio
.
Earlier, a news report published on the website of "Nature" magazine stated that US Department of Agriculture researchers conducted a new coronavirus antibody analysis study on the serum samples of some white-tailed deer in the states of Michigan, Illinois, New York and Pennsylvania and found that 1/3 The white-tailed deer sampled contained antibodies related to the new coronavirus.
Among them, 60% of the samples collected in Michigan had antibodies detected
.
According to a magazine, it is likely that after the deer herd was infected with the virus, the immune system resisted the infection and developed antibodies
.
This new study was published in the journal Nature on December 23 and published an article entitled "SARS-CoV-2 infection in free-ranging white-tailed deer"
.
The first report of white-tailed deer active COVID-19 infection supported by the growth of virus isolates in the laboratory was detailed, indicating that researchers have recovered live samples of the SARS-CoV-2 virus, not just its genetic traces
.
(The researchers provided an unedited version of this manuscript in order to obtain its findings as soon as possible.
) Based on the genome sequencing of samples collected between January and March 2021, the researchers determined that the variant that infected the wild deer was similar to that in Ohio at the time.
The SARS-CoV-2 virus strain that is prevalent in COVID-19 patients in the state matches
.
The sample collection occurred before the Delta variant spread widely, and the variant was not detected in these deer
.
The team is testing more samples to examine new variants as well as earlier variants.
The continued existence of these variants indicates that the virus can establish and survive in this species
.
Andrew Bowman, associate professor of veterinary preventive medicine at Ohio State University and the senior author of the paper, said that the fact that wild deer may be infected "makes people think that a new maintenance host may have been established outside of humans
.
"
Bowman said: "According to evidence from other studies, we know that they are exposed in the wild, we can infect them in the laboratory, and the virus can spread between deer
.
Here, we are talking about in the wild, they are infected
.
If They can maintain this virus, and we have a new potential source of SARS-CoV-2 to infect humans
.
This means that in addition to tracking people’s conditions, we also need to know what’s in the deer’s body
.
"This may complicate future COVID-19 mitigation and control plans
.
"There are still many unknowns: how the deer were infected, whether they can infect humans and other species, how the virus manifests in animals, and whether it is a short-term or long-term infection
.
The
research team collected 9 northeastern Ohio 360 white-tailed deer in the area nasal swabs
.
using PCR detection methods, the scientists detected in 129 (35.
8%) of the deer samples of genetic material to at least three different virus strains
.
deer six
.
The
analysis shows that in the first few months of 2021, the B.
1.
2 virus that dominates Ohio has spread to deer in different locations several times group
.
observed B.
1.
2, B.
1.
582 and B.
1.
596 virus may spread between deer and deer, so that the obtained virus spike protein (comprising the receptor binding domain) and the ORF1 amino acid substitutions, in which It is not common in humans
.
Bowman said: "Based on research results, it is shown that humans gave it to deer, and we gave it to them many times
.
We have evidence that six different viruses were introduced in these deer herds, and it was not that a single population was infected once and then spread
.
"Each site was sampled one to three times, for a total of 18 sample collection dates
.
According to the results of the study, the researchers estimated that the infection rate of these 9 sites ranged from 13.
5% to 70%, among which the infection rate in the four densely populated communities Location, the highest observed prevalence rate
.
Bowman said that white-tailed deer as a SARS-CoV-2 virus host may cause one of two results: the virus may mutate in the white-tailed deer, which may promote the spread of new mutant strains to other species (including humans); or The virus can survive in unmuted white-tailed deer, while it continues to evolve in humans, and at some point when humans have no immunity to strains that infect deer, these variants may spread to humans
.
How transmission occurred in these white-tailed deer in the first place, and how transmission occurred between species are open questions related to these discoveries
.
If these white-tailed deer have the same source of infection, other animals may also be exposed to this source of infection
.
The research team speculates that a variety of activities may allow white-tailed deer to come into contact with humans (and be infected with the new crown virus), including captive deer, field research, wildlife tourism, feeding and hunting
.
White-tailed deer may also be infected through environmental means—perhaps by drinking water contaminated by humans
.
Or contact with other infected species
.
Studies have shown that the new coronavirus can be transmitted through human feces and can be detected in wastewater
.
According to the official website of the "National Deer Association" of the United States, due to the impact of the new crown virus, in the autumn of 2020, Maryland and West Virginia have completely stopped sampling and testing for "chronic wasting diseases" that kill deer
.
This is the first time sampling and testing work has been stopped since the "chronic wasting disease" was first discovered in a herd of deer in Maryland in 2010
.
A spokesperson for the Maryland Department of Natural Resources said: “This is to prevent the spread of the new crown virus and protect the safety of workers and the public
.
” The white-tailed deer tested in this study are part of a population control plan, so they do not constitute Spread threat
.
Although it is estimated that there are 600,000 white-tailed deer in Ohio and about 30 million in the United States, Bowman said that this sample survey is concentrated in densely populated areas and does not represent all free-range deer
.
Reference materials: https://medicalxpress.
com/news/2021-12-covid-infection-deer-ohio.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity [Live Preview] New CRISPR technology combined with high-efficiency electrotransformation technology to help gene editing experience sharing, action knowledge practitioners-Single-cell Scientific Research Creation Camp (Wuhan Station) Popular·Article Basic Research [Science Sub-Journal] Transforming Artificial Lung-Lizard Provides an amazing method! Intestinal flora [Nature] Did you take hypoglycemic drugs ineffective? Because the intestinal microflora is in the process of cancer treatment [PNAS] Chinese medicinal materials thyme and oregano have found anti-cancer compounds for disease diagnosis and treatment [Nature Sub-Journal] This is another step towards changing the US$70 billion global diagnostic industry! Protein biosensors can measure toxic drugs for cardiovascular disease in cancer, arthritis, and organ transplant patients [JAMA Sub-Journal] Are you stressed? Stress increases the risk of cardiovascular disease! Scientific research [Cell Sub-Journal] Why do pain and anxiety speed up the breathing rate? The scientific research "Science" announced the breakthrough of 2021: A problem that has troubled biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!
