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Research funded by the NIH BRAIN initiative opens the door to link deep brain activity and behavior
Researchers are now able to directly wirelessly record the brain activity of patients with Parkinson's disease, and then use this information to adjust the stimulation of implanted devices
The project was published in the journal Nature Biotechnology and was funded by the National Institutes of Health's "Brain Research Through Advancing Innovative Neurotechnologies" (Brain) program
Dr.
The U.
Dr.
The significance of this record is significant
"If you want to use hospitalization records to change the disease state through adaptive stimulation, you must prove that they are also effective in the real world," said Dr.
Another benefit of long-term recording is that significant changes in brain activity (biomarkers) that can predict movement disorders can now be identified as individual patients
"Because we are able to build a biomarker library for each patient, we can now program each DBS unit according to the individual needs of the patient," said Dr.
An important issue to consider is the ethical implications of (almost) all-day brain recording
Dr.
These patients were also invited to participate in a neuroethics project funded by the NIH BRAIN initiative to determine concerns about this new technology (mh14860)
An unexpected benefit of this study is that because it requires almost no direct contact with clinicians after surgery, it is very suitable for social distancing, which is crucial during the COVID-19 pandemic
"The technology we have developed and used to communicate and work remotely with our patients can also allow those who do not live close to a clinic to receive updates on their equipment in the air and remote medical access to their neurologists to manage the increasingly complex DBS equipment, "Dr.
In the recent BRAIN 2.
This research was funded by the National Institutes of Health Brain Project (NS100544)
Original search:
Gilron, R.
et al.
, “Chronic wireless streaming of invasive neural recordings at home for circuit discovery and adaptive stimulation.
” Nature Biotechnology May 3, 2021.
DOI: 10.
1038/s41587-021-00897-5
