Nature Cancer of Sun Yat-Sen University found that mitochondrial fission promotes macrophage phagocytosis of cancer cells by regulating phase transition

Immunotherapy has revolutionized tumor treatme.

On April 28, 2022, the team of Su Shicheng of our hospital published the research results online in the journal Nature Cancer entitled Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition , and found that mitochondrial fission changes two important aspects of the phagocytosis machiner.

Mitochondria provide energy for immune responses (

Figure 1: Mitochondrial fission promotes tumor phagocytosis by macrophages

Actin polarization is a major step in the assembly of the phagocytic machinery when macrophages engulf large particles (

To explore whether antibody-mediated phagocytosis of tumor cells is related to mitochondrial fission in macrophages, the authors used microarray, Western blot, mass spectrometry and Ocomine database to detect the expression of differential proteins in tumor cell lines resistant and sensitive to prophagocytic antibodi.

Collectively, the present study revealed that the competition of glutamine in the tumor microenvironment inhibits mitochondrial fission and maintenance of WIP/WASP phase separation in macrophages through the study of different antibody-mediated tumor phagocytosis models, thereby inhibiting PKC-θ Polarization of phosphorylated WIP and Actin, ultimately resulting in clinical antibody resistan.

Figure 2: Schematic diagram of the main mechanism of the project

Professor Su Shicheng is the corresponding author of the paper, and postdoctoral fellow Li Jiang, doctoral students Ye Yingying, Liu Zhihan and .

 Paper link: https://