NATURE: Chinese researchers to Wuhan new crown transmission of a comprehensive dynamic reconstruction?

!---- As countries around the world review interventions to contain the COVID-19 pandemic, important lessons can be drawn by studying the overall transmission dynamics of SARS-CoV-2 in Wuhan, Chinain Wuhan, aggressive non-drug intervention snouts the outbreak of local COVID-19recently, researchers from Wuhan Huazhong University of Science and Technology and Harvard University recently worked together to reconstruct the full spectrum dynamics of COVID-19 between January 1, 2020 and March 8, 2020, based on the events of 32,583 laboratory-confirmed cases and the five periods marked by interventionstaking into account pre-symptom infectiousness, the rate of diagnosis, transmission and population movements, the researchers identified two key characteristics of the outbreak: high coverage and high transmissionresearchers estimate that 87% of infected people by March 8 (53% of the lower limit) are undiagnosed, which may include cases of asymptomatic and mild symptoms;researchers observed that multi-pronged interventions had a significant positive effect on controlling the outbreak, reducing the number of reproductions to 0.28 (0.23-0.33), and that the total number of infections in Wuhan had decreased by 96.0% as of March 8researchers further explored the probability of recurrence after 14 days of undiagnosed infection, estimated at 0.32 and 0.06, respectively, based on 87% and 53% of undiagnosed infections, highlighting the risks associated with no confirmed cases in changing intervention strategiesthese results provide significant importance for the continuation of monitoring and intervention sending the outbreak of COVID-19 to an end.