NATURE: Dietary restrictions combined with hormone therapy can long-term promote breast cancer subsidy.

Studies have shown that about all breast cancer cells express estrogen and or progesterone receptorsEndocrine therapy is usually effective for these hormone receptor-positive tumors but primary and acquired resistance limits its long-term useHere, researchers found that regular fasting or fasting in a mouse's hormone-positive breast cancer model can enhance the activity of endocrine therapy drugs tamoxifen and fuvisin, which is achieved by raising and suppressing signals to reduce circulating insulin and leptin levelsWhen used in conjunction with a cycline-dependent kinase inhibitor, the inclusion of a periodic fasting simulated diet can promote long-term tumor recourse and reverse acquired resistance to drug therapyIn addition, fasting and an fasting simulated diet can prevent endometrial hyperploff caused by tamoxifenPeriodic fasting simulated diets in patients with hormone-receptor-positive breast cancer treated with estrogen cause metabolic changes similar to those observed in mice including insulin, leptin, and lower levels of both remainlow for long periods of timeThese lasting effects in mice are associated with long-term anti-cancer activityThese results support further clinical studies to use the fasting simulated diet as an aid to estrogen therapy for hormone-receptor-positive breast cancer