Nature: Drinking alcohol causes an overt genetic change in the brain's memory center.

Original title: Nature: Drinking alcohol leads to metastogenesital changes in brain memory centers
Recently, researchers at

University of Pennsylvania's Perelman
Institute of Medicine
published a study entitled "Alcohol me
tabolism co
ntributes to Brain histone acetylation" article found that the acetylation effect of
alcoal
metabolism
products on the brain group
protein
provides new methods and strategies for treating alcohol abuse and
protective
fetal alcohol syndrome.
many studies have shown that metastrogeneic regulation depends on metabolic state and involves specific metabolic factors. In neurons, the acetylation of histones depends on the metabolite acetyl coenzyme A, which is produced by the chromatin-binding acetyl coenzyme A synthase 2 (Acetyl-CoA synthetase 2, ACSS2) catalytic acetate. It is worth noting that the liver breaks down alcohol leading to a rapid increase in the blood acetic acid content, so alcohol is the main source of acetic acid in the human body. Therefore, histoprotein acetylation in neurons may be affected by acetic acid derived from alcohol.
researchers used stable isotope markers in mice to shed light on the process by which alcohol metabolism causes rapid acetylation of histones in the brain. The process relies on ACSS2, which "precipitates" the acetyl produced by alcohol metabolism directly to hisoproteins. A similar acetylation process was observed when the mice were injected with heavy label acetic acid. When pregnant mice are exposed to isotope-labeled alcohol, the labeled acetylase binds to histones in the brain of the pregnant fetus. In the original hema neurons in ionosomes, extracellulated acetic acid induces transcription procedures associated with learning memory, which are sensitive to ACSS2 inhibition. The study showed a direct link between acetylation and gene regulation of hismoglobin in the brain through ACSS2. (Excerpted from Nature, Published: 23 Oct 2019)
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