Nature Good wen: Tracing the origin of the new crown virus.

On June 5, nature published the paper "the big sister: what it will take to trace the coronavirus source", summarizing various views on the source of the new coronavirus.the source of new coronavirus has been one of the most difficult problems since the beginning of the epidemic.although it is almost certain that bats are the source, there is still no clear answer on how to transmit them to humans.it has been explained that bats transmit the virus to intermediate hosts and then to humans.in mid May, who called on international organizations to work together to trace the origin of the new coronavirus.according to some scientists, it is very difficult to find animal origin and completely exclude Wuhan Virus Research Institute as the source.Wuhan Virus Research Institute is a laboratory for bat coronavirus research. Unfortunately, it happens to be located in the city where the epidemic first appeared.and, unfortunately, some of the research work of the Institute has attracted people's attention.an independent investigation into the Wuhan Virus Research Institute may provide convincing evidence to exclude the laboratory as the source, but such an investigation is impossible due to the complex geopolitics.animal origin 01 the latest study in China analyzed the partial sequences of about 1240 coronaviruses in bats. It was found that sars-cov-2 was most closely related to a group of viruses found in Rhinolophus.the NCV seems to have originated in Yunnan, but the team only collected virus samples from Chinese sites, so they could not rule out that sars-cov-2 might have come from neighboring Myanmar and Laos, where horseshoe bats are also found.Shi Zhengli, a researcher at Wuhan Institute of Virology, was particularly concerned during the pandemic because of her work on coronavirus research.researcher Shi said she had warned animals of the risk of another SARS like disease.Volker Thiel, a virologist at the University of Bern, says she has actually warned us that bat viruses exist in nature and that they can be transmitted to humans.If a virus almost the same as sars-cov-2 can be found in animals, it can be explained how the virus is transmitted to humans.however, this requires a large number of samples of coronaviruses from wild animals and plants in China.it is reported that China has started such an investigation, but there is little information about it.it may take a long time to identify the animal origin of sars-cov-2.a similar survey was conducted after the outbreak of SARS.the first case appeared in November 2002 and was not identified as coronavirus until April 2003. It took nearly 15 years and a lot of animal sampling work to determine the source of the virus was bats.the virus has been studied around the world using methods including computational models, cytobiology and animal experiments, but so far it is still elusive.the laboratory speculates that 02 Wuhan Virus Research Institute is one of dozens of biosafety level 4 (P4 laboratories) in the world.although there is no evidence to support where the virus came from, it will be tricky and time-consuming to completely exclude this possibility.there are also coronaviruses associated with sars-cov-2 in the laboratory. If the staff members are accidentally infected by the virus samples and then transmit them to outsiders, the virus may spread.but the above is also hypothetical and there is no evidence.in April, the director of the Institute said that the virus was definitely not produced in the laboratory and that researchers knew how to manage virus samples.in 2017, nature visited the P4 laboratory in Wuhan, and the Dean showed nature new equipment, high safety test room and well-designed ventilation system, which can ensure that pathogens are safely controlled.the president said that his team had worked with French biosafety scientists to establish the world's most advanced biosafety research laboratory.the agency has no record of accidents.forensic investigation is needed to determine whether the laboratory is related to the virus, according to scientists.it is necessary to take samples from the laboratory, interview staff, review laboratory books and safety accident records, and see what type of experiments the researchers are doing.Frank Hamill, a former manager of P4 laboratories in the United States, said such an investigation may not produce any decisive results.even the biosafety laboratories in the United States are not completely open and transparent about their research contents, and it is a bit hypocritical to ask Wuhan Virus Research Institute to accept public investigation. products of nature 03 some scientists outside China have studied the genome of this virus in detail and have concluded that the virus is a natural product, not a laboratory product. An analysis report published on March 17 in the journal Nature Medicine discussed several abnormal features of the virus and suggested that they might be caused by natural processes. first of all, researchers must use the RNA of the existing coronavirus as the skeleton when trying to genetically modify the virus. if scientists study new coronaviruses, they are likely to use known skeletons. in order to enter cells, the coronavirus uses a "receptor binding domain" (RDB) to lock onto receptors on the cell surface. The RBD of sars-cov-2 is different from any other coronavirus. although experimental evidence suggests that the virus binds to human cells successfully, it does not bind well. the authors believe that no one has tried to design a virus to design RBD, so it is likely to be the result of natural selection. the authors also pointed out another unusual feature of sars-cov-2, which is also part of the mechanism that helps the virus to enter human cells, i.e. the cleavage site of Flynn protease. the author thinks that natural process can explain how this feature appears. indeed, similar sites have been found in coronavirus, which supports the author's view that the components of sars-cov-2 may come from natural processes. the main authors of the paper said that sars-cov-2 is unlikely to be produced or operated in the laboratory, they have a lot of data to show that it is natural, and there is no data or evidence to show any connection with the laboratory. Jack Nunberg, a virologist at the University of Montana in Missouri, said it was unlikely that there was a signature signal that the genome was manipulated, and he did not believe that the virus came from a laboratory. he said, for example, if scientists added a description of the cleavage site of the Flynn protease into the genome of the virus, it would be impossible to know whether the site was inserted in humans or in nature. it will be very difficult or even impossible to prove or disprove the theory that the virus is released by the laboratory. It is hoped that governments will be better prepared for the next pandemic. Yaodu app "new play of points" company enjoys the super value rights of the database. Scan the QR code, buy books and unlock your professional tools immediately!