"Nature" Harvard University has discovered signaling molecules that help prevent Alzheimer's disease

A new study in humans and mice has discovered a special signaling molecule that can help regulate inflammation and the immune system to prevent Alzheimer’s

When neurons begin to die, the cognitive decline associated with Alzheimer's disease develops

Once neurons begin to die more and more, microglia and astrocytes become active to cause neuroinflammation and try to protect the brain

In the case of Alzheimer's disease, neuronal cell death caused by beta amyloid deposits and tau tangles activates this response

This new study in the journal Nature shows that a part of astrocytes actually try to extinguish the fire by releasing a molecule called interleukin-3 (IL-3), and then interleukin-3 will kill Sex microglia are transformed back into nourishing and protective cells, no longer destroying neurons, but focusing on removing amyloid beta deposits and tau tangles

Swirski said: "Knowing that astrocytes talk to microglia through IL-3 to educate microglia and help them reduce the severity of Alzheimer's disease may have important clinical significance

"It is surprising to find IL-3 in the brain," said first author Cameron McAlpine, a lecturer at the Center for Systems Biology

Original search: Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease