Nature Heavyweights . . . The origin of the new coronavirus has been declassified, and many teams such as South China Agricultural University have found that the new coronavirus may have been the result of a recombination of the pangolin coronavirus and the bat coronavirus.

Due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 has attracted worldwide attention. The pathogen was identified as sars-cov-2.novel coronavirus pneumonia has been diagnosed by more than 3 million 850 thousand cases and 260 thousand deaths worldwide, according to the real-time statistics published by Johns Hopkins University at present (May 7th).these figures are updated daily and are expected to increase further.although bats may be the host of sars-cov-2, the identity of any intermediate host that may contribute to the transfer to humans is unclear.on May 7, 2020, Xiao Lihua, Shen Yongyi of South China Agricultural University and Chen Wu of Guangzhou Zoo published a joint communication entitled "isolation of sars-cov-2-related coronavirus from Malaysia" in nature A coronavirus isolated from Malaya pangolins has 100%, 98.6%, 97.8% and 90.7% amino acid identity with sars-cov-2 in E, m, N and s genes, respectively.in particular, the receptor binding domain of S protein of pangolin cov is actually the same as that of sars-cov-2, with a non key amino acid difference.comparative genomic analysis showed that sars-cov-2 could be derived from the recombination of pangolin cov-like virus and bat-cov-ratg13-like virus.among the 25 species of Malaya pangolin analyzed, 17 were found to have pangolin coronavirus.the infected pangolins showed clinical symptoms and histological changes, and the circulating antibodies against pangolin cov reacted with the S protein of sars-cov-2.the isolation of coronavirus highly related to sars-cov-2 in pangolin indicates that they have the potential to act as intermediate hosts of sars-cov-2.if the trade in wild animals and plants cannot be effectively controlled, the newly discovered coronavirus may pose a threat to public health.in addition, on March 26, 2020, Guan Yi of Hong Kong University and Hu Yanling of Guangxi Medical University published a joint communication entitled "identifying sars-cov-2 related coronaviruses in Malaysia" online in nature In this study, a number of samples of pangolins seized in Guangxi and Guangdong anti smuggling operations were detected, and coronavirus was found in pangolins samples, which belongs to two subtypes of the new coronavirus, and one of the receptor binding domain is closely related to the new coronavirus. A novel coronaviruspangolin virus and its similarity with SARS-CoV-2 revealed that pangolin should be considered as the possible host of new coronavirus. The study emphasized that it is forbidden to ban wild animal such as pangolin and other wild animals.on March 19, 2020, the team of Zhang Zhigang of Yunnan University published the title "possible pangolin origin of sars-cov-2 associated with the covid-19" online in current biology This study re assembled and comprehensively analyzed the previously published viral genomic data of Malay pangolin beetles (the data were obtained from the lung samples of pangolin beetles that could not be rescued successfully on March 24, 2019). It was found that these Malay pangolin beetles carried coronaviruses similar to sars-cov-2 (named pangolin COV), which were similar to sars-cov-2 and batcov The genomic similarity of ratg13 was 91.02% and 90.55%, respectively.in conclusion, this study suggests that pangolin species are a natural reservoir of sars-cov-2.at the same time, the study also calls for strengthening wildlife protection and management. To protect wildlife is to protect human beings (click read).due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 has attracted worldwide attention. 's novel coronavirus infection is believed to be transmitted from animal and pathogen is identified as SARS-CoV-2. by January 2020, it is suspected that the initial infected patients were infected with the virus through human to human transmission. since January 2020, the virus has spread rapidly to most parts of China and other countries. due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 quickly attracted global attention, and the pathogen was identified as sars-cov-2. novel coronavirus pneumonia has been diagnosed by more than 3 million 850 thousand cases and 260 thousand deaths worldwide, according to the real-time statistics published by Johns Hopkins University at present (May 7th). these figures are updated daily and are expected to increase further. pangolin novel coronavirus may induce pathological changes in pangolin lung (Nature) is similar to SARS-CoV and MERS-CoV. Bat is still a possible origin of the new coronavirus (SARS-CoV-2) in 2019. however, SARS CoV and mers cov usually enter intermediate hosts, such as civet or camel, before entering humans. this fact suggests that sars-cov-2 may have been transmitted to humans through other animals. considering that the earliest covid-19 patient reports have not been exposed in the seafood market, it is important to find an intermediate host of sars-cov-2 to prevent interspecific transmission. genome characterization of pangolin coronavirus (image from nature) in this study, a coronavirus isolated from Malaya pangolin had 100%, 98.6%, 97.8% and 90.7% amino acid identity with sars-cov-2 in E, m, N and s genes, respectively. in particular, the receptor binding domain of S protein of pangolin cov is actually the same as that of sars-cov-2, with a non key amino acid difference. comparative genomic analysis showed that sars-cov-2 could be derived from the recombination of pangolin cov-like virus and bat-cov-ratg13-like virus. among the 25 species of Malaya pangolin analyzed, 17 were found to have pangolin coronavirus. the infected pangolins showed clinical symptoms and histological changes, and the circulating antibodies against pangolin cov reacted with the S protein of sars-cov-2. the isolation of coronavirus highly related to sars-cov-2 in pangolin indicates that they have the potential to act as intermediate hosts of sars-cov-2. if the trade in wild animals and plants cannot be effectively controlled, the newly discovered coronavirus may pose a threat to public health. reference message: