Nature: immune escape occurs before tumor invasion in early lung cancer
Last Update: 2020-06-19
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In a new study, researchers from France, Belgium and the United States found that immune activation and immune evasion occurred before tumor invasion, and explained the related immune biomarkers in the pre invasion stage of lung cancerThe relevant research results were published online in the nature Journal on June 26, 2019, and the paper title is "immune evaluation before tumour investment in early lung squamous carcinogenesis"< br / > the researchers used gene expression profiling and multispectral imaging to analyze data sets from nine morphological stages of lung squamous cell carcinoma production, including 122 well annotated living tissue samples from 77 patients< br / > these researchers identified evolutionary pathways of cancer and immune pathways, including (1) a linear increase in proliferation and DNA repair from normal to cancerous tissues; (2) a transient increase in metabolism and early immunoassay by activating resident immune cells in low-grade pre invasion lesions; (3) Finally, (4) the activation of epithelial mesenchymal transition (EMT) in the stage of cancer invasionBased on this, they proposed that the occurrence of lung cancer involves the dynamic coevolution of pre invasion bronchial cells and immune response< br / > to sum up, these results highlight the need to develop immunobiomarkers for early detection, as well as immunotherapy based chemoprevention methods for high-risk groups of lung cancer< br / > reference: C é line mascaux et alImmune evaluation before tumour investment in early lung squamous carcinogenesisNature, 2019, doi:10.1038/s41586-019-1330-0.
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