Nature Immunology: Li Huabing/Yi Chengqi/Wu Yuzhang collaborated to reveal a new mechanism by which tRNA-m1A modification modulates the function of CD4+ T cells

Recently, Li Huabing, a researcher at Shanghai Jiao Tong University School of Medicine, Professor Yi Chengqi of the School of Life Sciences of Peking University, Wu Yuzhang of the Army Military Medical University, and Richard Flavell of Yale University School of Medicine, collaborated with a team entitled "tRNA-m1A modification promotes T cell expansion via efficient MYC protein.

This study revealed that the m1A-modified catalytic enzyme TRMT61A accelerates the translation of a variety of key proteins after CD4+T cell activation by catalyzing the 1-methyladenine (m1A) modification of the newly synthesized tRNA 58th position adenine, ensuring a rapid immune response

This study is the first to elucidate in detail the molecular mechanisms

T cells play a central role

tRNAs play an important role

The study first observed that protein translation-related pathways were regulated during T cell activation, and different tRNAs also showed dynamic expression patterns of upregulation at different time points, and the tRNA-m1A58 modifier enzyme TRMT6/TRMT61A was also upregulated

The authors then explore the specificity

The study is the first to link tRNA modifications to changes in the function of T cells and systematically explore the specific mechanisms that control translation during primary T cell amplification, showing that the use of tRNA and its modifications can bring about significant changes

TRMT61A-mediated tRNA-m1A58 modification is a "translation checkpoint" for CD4+ T cell activation and proliferation regulation

Dr.

Original Source:

Liu， Y.