Nature: Is the concentration of antibodies in the plasma of the newly crowned healer too low?

During theCOVID-19pandemic, the SARS-CoV-2infected millions of people and claimed hundreds of thousands of livesthe virus enters the cell depends on the receptor binding domain (RBD) of the SARS-CoV-2 sting protein (S)Although there is no vaccine available today, antibodies are likely to be the key to protecting the bodySo far, however, we know very little about the human antibody response to SARS-CoV-2recently, researchers looked at 149 COVID-19 patientsThe plasma collected over an average of 39 days after symptoms had different half of the largest pseudovirus and the titration: 33% were less than 1:50, 79% were less than 1:1000, and only 1% showed a titer above 1:5000antibody sequencing showed that the expanded cloning of RBD-specific memory B cells in different individuals expressed antibodies that were closely related to themAlthough plasma titer is low, half of the maximum inhibitory concentration (IC50 value) of antibodies neutralized in three different tables on RBD is as low as a single digit ng/ml, most plasma obtained from COVID-19 recoverers does not contain high levels of neutralactivityhowever, rare but recurring RBD-specific antibodies with strong antiviral activity were found in all the people tested, suggesting that vaccines designed to cause the antibodies may be widely effective