Nature journal: Shanghai Jiaotong University's Zhao Yilei team discovered the longevity of nematodes that eat DNA sulfur-modified bacteria

Recently, the Nature series of journals Communications biology published an article by Professor Zhao Yilei’s research team from the School of Life Sciences and Technology of Shanghai Jiaotong University and the State Key Laboratory of Microbial Metabolism, “Phosphorothioate-DNA bacterial diet reduces the ROS levels in C.
elegans while improving locomotion and longevity” (Doi: 10.
1038/s42003-021-02863-y)
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This achievement was completed in collaboration with the team of Academician Deng Zixin of the State Key Laboratory of Microbial Metabolism.
Doctoral student Huang Qiang is the first author of the paper.
Associate Professor Cong Fengsong from the School of Life Sciences and Technology, Professor Yi Tao of Fudan University, and Professor Wang Dayong of Southeast University are the co-authors of this article
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This work used DNA sulfur-modified bioengineered bacteria and control bacteria to feed Caenorhabditis elegans to study the physiological effects of long-term intake of PT-DNA substances on eukaryotes
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Microbiological analysis shows that there are a large number of sulfur-modified bacteria in the human gut microbiota, but their potential effects on the host are still unclear
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Zhao Yilei’s research team started by measuring the level of ROS in the nematodes and found that the active oxygen levels in young nematodes who had long-term intake of sulfur-modified bacteria decreased significantly.
Specific fluorescence probe experiments showed that peroxynitrite ROS molecules decreased most significantly
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At the same time, their levels of lipofuscin, a marker of aging, have also decreased, but their individual activity has increased and their life span has been prolonged
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The resistance to acute oxidative stresses such as paraquat, heavy metal chromium ions, and heat shock has also been enhanced
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Differential transcriptomics sequencing analysis showed that the expression of hundreds of genes in the actively eating young nematodes was significantly regulated, including the anti-ROS gene sod-3, heat shock protein hsp12.
6, and glutathione sulfur transferase genes (GSTs) Significant changes have taken place in the life-regulating gene jnk-1, etc.
These regulated genes are enriched in biological processes such as protein phosphorylation, neural receptors, DNA replication and repair, and are very likely to affect the insulin signal related to the daf-16 gene.
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The phenotypic mechanism of Caenorhabditis elegans that eats sulfur-modified bacteria.
Professor Zhao Yilei has been engaged in the research of PT-DNA anti-oxidation and molecular recognition for a long time
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The work of this paper is their continuous report on PT-DNA double helix structure perturbation (JPCB-2012), upstream and downstream sequence correlation (JPCB-2015), anti-Fenton reagent (SciRep-2017), anti-peroxynitrite (ACS) Chem.
Biol.
-2020) and another systematic research progress
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This work was funded by the General Program of the National Natural Science Foundation of China and the key R&D project of the Ministry of Science and Technology
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Link to the paper: https:// 2020 hot articles selection 1.
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