Nature Medicine . . . Breakthrough, Yuan Guoyong team for the first time to obtain the new coronavirus can infect the bat direct evidence.

Due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 has attracted worldwide attention. The pathogen was identified as sars-cov-2.novel coronavirus pneumonia has been diagnosed by more than 4 million 700 thousand cases and 310 thousand deaths worldwide, according to the real-time statistics published by Johns Hopkins University at present (May 17th).these figures are updated daily and are expected to increase further.it has been suggested that Rhinolophus sinicus (R. sinicus) is a natural host of SARS CoV. However, there was no direct evidence of SARS CoV infection in these bats.on May 13, 2020, the team of Yuan Guoyong of the University of Hong Kong published a research paper entitled "infection of bat and human intelligent organizations by sars-cov-2" online in nature medicine. The study found that bat derived organs were completely sensitive to sars-cov-2 infection and could maintain a strong viral replication capacity.this study established the first scalable organ like culture system of bat intestinal epithelium and provided evidence that sars-cov-2 could infect bat intestinal cells.the strong replication of sars-cov-2 in human intestinal organs suggests that human gut may be the transmission route of sars-cov-2.due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 has attracted worldwide attention.'s novel coronavirus infection is believed to be transmitted from animal and pathogen is identified as SARS-CoV-2.by January 2020, it is suspected that the initial infected patients were infected with the virus through human to human transmission.since January 2020, the virus has spread rapidly to most parts of China and other countries.due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 quickly attracted global attention, and the pathogen was identified as sars-cov-2.novel coronavirus pneumonia has been diagnosed by more than 4 million 700 thousand cases and 310 thousand deaths worldwide, according to the real-time statistics published by Johns Hopkins University at present (May 17th).these figures are updated daily and are expected to increase further.it has been suggested that Rhinolophus sinicus (R. sinicus) is a natural host of SARS CoV.however, there is no direct evidence of SARS CoV infection in these bats, which may be due to the nature of acute and self limiting infection, seasonal fluctuations in virus growth in these bats, and difficulty in contacting these animals in the wild.therefore, the lack of readily available in vitro models that can faithfully represent natural bat cells is a major obstacle to the isolation and study of bat viruses, including bat SARS CoV, which are considered to have high zoonotic potential.in the past decade, great breakthroughs have been made in the generation of organoids.an organ like culture system based on adult stem cells (ASC) has been established for most human organs, including the production of human gut like organs and lung like organs.although undifferentiated gut like organs can be expanded for more than one year, after induction, differentiated intestinal organs will faithfully mimic the multicellular composition and functional complexity of human intestinal epithelium.because human gastrointestinal tract is one of the most common ways of microbial invasion, human intestinal organs have become common tools in vitro to simulate intestinal infection.in this study, the researchers attempted to establish an ASC based organoid culture of bat intestinal epithelium.this study found that bat derived organoids were completely sensitive to sars-cov-2 infection and maintained a strong viral replication capacity.this study established the first scalable organ like culture system of bat intestinal epithelium and provided evidence that sars-cov-2 could infect bat intestinal cells. The strong replication of sars-cov-2 in human intestinal organs suggests that human gut may be the transmission route of sars-cov-2.reference message: