Nature Nanotechnology: Liu Gang's team from Xiamen University developed a new nanovesicle vaccine platform that can mediate super anti-tumor immune activity

Malignant tumors are a serious threat to human health.

Depends largely on the interaction between T cells and antigen presenting cells (APCs)

Furthermore, in the tumor immune microenvironment, antigen-specific CTL responses are often inhibited by immune checkpoints

Recently, the team of Prof.

A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

This study discovered an important mechanism of co-stimulatory signaling on the remodeling of T cell function in tumor immune tolerance , and reported for the first time a biomimetic cell membrane vesicle that can directly activate both naive T cells and exhausted T cells to fight tumors.

An important mechanism of co-stimulatory signaling for remodeling of T cell function in tumor immune tolerance A biomimetic cell-membrane vesicle anti-tumor vaccine strategy that can directly activate both naive and exhausted T cells is reported for the first time for personalized tumors Vaccine research and development provides theoretical basis and innovative methods

At the same time, Nature Nanotechnology distributed a special highlight review article: Boosting dendritic cell nanovaccines, commenting that this work breaks through the existing cognitive framework of dendritic cell vaccines and promotes a big step forward in the field of nanovaccine immunology

In this work, based on the cell membrane biomimetic directional expression display technology created by the research group (Adv Mater 2019, Angew Chem 2018, PNAS 2015, et al.

Vesicle vaccine preparation and characterization

Vesicle vaccine preparation and characterization

The prepared ASPIRE vaccine system, because it is derived from functional chemokines and adhesion molecules related to homing effect on the surface of dendritic cell blast cells, and controllable nanometer size, can quickly pass through the interstitial space and achieve in the lymph node.

ASPIRE vaccine mediates robust antitumor effects

ASPIRE vaccine mediates robust antitumor effects

In this study, the authors discovered the necessity of B7-CD28 co-stimulatory signaling for PD-1 antibody therapy.

In addition, another important finding in this study is that the response of T cells in the tumor immune microenvironment to PD-1 antibody and antigen stimulation is different in time and space.

Schematic diagram of ASPIRE vaccine-mediated multidimensional T cell activation

Schematic diagram of ASPIRE vaccine-mediated multidimensional T cell activation

This study describes a novel vaccine strategy that can activate both naive T cells and exhausted T cells, and demonstrates the superior anti-tumor immune activity mediated by ASPIRE through anti-tumor animal experiments

The research was supported by the major special projects of the Ministry of Science and Technology and the National Natural Science Foundation of China Distinguished Young Scholars Fund

Postdoctoral fellows Liu Chao and Liu Xue from the School of Public Health of Xiamen University are the co-first authors of the paper, and Professor Liu Gang and Professor Chen Xiaoyuan from the National University of Singapore are the co-corresponding authors of the paper

 

Original source:

Original source:

Liu, C.

Liu, C.
, Liu, X.
, Xiang, X.
et al.
A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy.
Nat.
Nanotechnol.
(2022).
https://doi.
org/ 10.
1038/s41565-022-01098-0.


Leave a message here