Nature. Research by the South China Agricultural University shows that the new coronavirus is recombined by pangolin coronavirus and bat coronavirus.

Novel coronavirus pneumonia was diagnosed in the world as of 24 May 7th. More than 3 million 800 thousand patients were diagnosed with new crown pneumonia, and more than 260 thousand patients died. The outbreak has been almost 5 months ago. However, there is no specific drug or vaccine.in addition to isolation and treatment, and accelerating the development of specific drugs and vaccines, it is also necessary to clarify the natural host and intermediate host of the virus as soon as possible, so as to better and faster overcome the virus.on May 7, nature, a top international academic journal, launched a research paper entitled isolation of sars-cov-2-related coronavirus from Malaysia pangolins by Shen Yongyi and Xiao Lihua of South China Agricultural University in the form of accelerated review articles.the research team isolated a coronavirus with high homology with new coronavirus (sars-cov-2) from Malaya pangolin. The results of comparative genomic analysis showed that sars-cov-2 could be derived from the recombination of pangolin coronavirus like virus and bat coronavirus ratg13 like virus.pangolin pangolin is widely hunted and sold in Asia as food and traditional Chinese medicine.since 1990, pangolin has been listed in Appendix II of cites, and any commercial use of hunting from the wild is prohibited.in China, pangolin belongs to the second class protected animal of the state. It is forbidden to kill, eat, illegally hunt, smuggle or sell. If the case is serious, it can be sentenced to life imprisonment.at present, pangolin has been listed in the World Conservation Union (IUCN) 2014 red list of endangered species ver 3.1 - extremely endangered (CR).extreme risk means that the species is facing the highest threat and crisis level, which is second only to extinction and wild extinction.this rating means that the wild population of pangolin is highly likely to be extinct. The outbreak of novel coronavirus pneumonia (COVID-19) inhas brought hitherto unknown challenges to global health.the new coronavirus (sars-cov-2) has high sequence homology with SARS CoV and bat coronavirus ratg13.although bats may be the host of various coronaviruses, it is still unclear whether sars-cov-2 has other hosts.in this study, a coronavirus isolated from Malaya pangolin had 100%, 98.6%, 97.8% and 90.7% amino acid identity with sars-cov-2 in E, m, N and s genes, respectively.in particular, the receptor binding domain of S protein of pangolin coronavirus is actually the same as that of sars-cov-2, with only one non key amino acid difference. The results of comparative genomic analysis showed that sars-cov-2 could be derived from the recombination of pangolin coronavirus like virus and bat coronavirus ratg13 like virus.among the 25 species of Malaya pangolin analyzed, 17 were found to have pangolin coronavirus.the infected pangolins showed clinical symptoms and histological changes, and the circulating antibodies against pangolin cov reacted with the S protein of sars-cov-2. The authors believe that the isolation of coronavirus highly related to sars-cov-2 in pangolin indicates that pangolin has the potential to act as an intermediate host of sars-cov-2. in addition, the authors stress that if the trade in wild animals and plants is not effectively controlled, the newly discovered coronavirus in pangolin, a mammalian species that is most trafficked, may pose a future threat to public health. The novel coronavirus is a potential intermediate host of the new type of coronavirus, South China Agricultural University reported in February 6th, according to the official announcement of . this is the first time that pangolin may be the intermediate host of the new coronavirus. on March 26, Guan Yi's team published a research paper entitled "identifying sars-cov-2 related coronaviruses in Malaysia pangolins" in nature. Guan Yi's team tested several pangolin samples seized during the anti smuggling operations in Guangxi and Guangdong, and found new coronavirus related coronavirus in the pangolin samples, which belong to two subtypes of the new coronavirus, and one of the receptor binding domain is closely related to the new coronavirus. found novel coronavirus coronavirus multiple lineages and its similarity with the new crown virus. It is suggested that pangolin should be regarded as the possible intermediate host of the new coronavirus, and it is emphasized that wild animal such as pangolin should be banned in the market. details: pangolin! Professor Guan Yi's discovery of new coronavirus from smuggled pangolins? On January 22, the Journal of Medical Virology published a research paper jointly completed by Peking University, Guangxi University of traditional Chinese medicine, Ningbo University, Wuhan Institute of bioengineering and other units, entitled: biomedical recommendation within the spike glycoprotein of the newly identified coronavirus may boost cross ‐ species transmission from snake to human. Novel coronavirus 2019-nCoV is the most potential animal bank for the outbreak of 2019-nCoV infection in the new type of cov in China. however, this conclusion has not been widely accepted by researchers in the industry, because synonymous codon usage bias analysis is not suitable for studying the host of coronavirus, so the conclusion of this paper is not necessarily reliable. the natural host of NCV is still bats. On February 3, nature, a top international academic journal, launched the research paper of Shi Zhengli team from Wuhan Institute of Virology, Chinese Academy of Sciences (the main content of this paper was published in the preprint biorxiv on January 23). since the outbreak of SARS 18 years ago, a large number of severe acute respiratory syndrome associated coronavirus (sarsr COV) has been found in bats. Previous studies have shown that some bat derived SARS associated coronaviruses may infect humans. novel coronavirus pneumonia novel coronavirus is reported and characterized by Shi Zhengli team in this paper. at the early stage of the outbreak, Shi Zhengli's team obtained the full-length genome sequence of the virus from five patients. these viruses are almost identical to each other, and have 79.5% genome sequence similarity to SARS coronavirus. sequence analysis of seven conserved nonstructural proteins showed that the virus belonged to the species of SARS r cov. novel coronavirus has 96% homology with bat coronavirus at the whole genome level. it is confirmed that the natural host of the new coronavirus is bat. most importantly, this study revealed that the new coronavirus and SARS CoV use the same receptor ACE2 to enter cells at the molecular level. the intermediate host is mink? On January 25, Zhu huaiqiu of Peking University and Xiao Yonghong of Zhejiang University jointly published a research paper entitled "host and Effectiveness Prediction of Wuhan 2019 new coronavirus using deep learning algorithm" online in the preprint biorxiv. by comparing the infection patterns of all the viruses in vertebrate hosts, it was found that mink virus showed a more similar infection pattern to the new coronavirus. these results of infectivity pattern analysis suggest that mink may be the intermediate host of NCV. the intermediate host is pangolin? In February 6th, novel coronavirus was found to be the potential intermediate host of the new type of coronavirus, South China Agricultural University reported. The team identified novel coronavirus as potential intermediate host by analyzing more than 1000 metagenomic samples. Then, by means of molecular biological tests, the positive rate of PCOS in pangolin was revealed to be 70%. Further isolation and identification of viruses were carried out, and typical coronavirus particles were observed under electron microscope. The sequence similarity between the isolated virus strain and the current human strain was as high as 99%. is the first novel coronavirus to be the potential intermediate host of new coronavirus. on February 18, Professor Guan Yi and Professor Hu Yanling of Guangxi Medical University published the latest research paper entitled "identification of 2019 ncov related coronaviruses in Malaysia pangolins in southern China" on the preprint website biorxiv. the research team detected a number of pangolin samples seized in Guangxi and Guangdong anti smuggling operations, and found new coronavirus related coronavirus in pangolin samples, belonging to two subtypes of the new coronavirus, and one of the receptor binding domain is closely related to the new coronavirus. found that the novel coronavirus coronavirus multiple lineages and their similarity with the new crown virus showed that pangolin should be regarded as the possible intermediate host of the new coronavirus. Novel coronavirus, , what kind of wild animal is the intermediate host of this new coronavirus? Mink? Pangolin? Or other animals? It is still not entirely clear that what we can do is to stay away from wild animals and refuse to contact, illegally capture and eat wild animals. paper links: