Nature: Significant progress!

In a new study, researchers from research institutions such as the Barcelona Institute of Science and Technology in Spain and the Fernberg School of Medicine of Northwestern University in the United States revealed how palmitic acid changes the cancer genome and increases the possibility of cancer spreading
.

They have begun to develop therapies that interrupt this process and say that clinical trials may begin in the next few years

In a new study, researchers from research institutions such as the Barcelona Institute of Science and Technology in Spain and the Fernberg School of Medicine of Northwestern University in the United States revealed how palmitic acid changes the cancer genome and increases the possibility of cancer spreading

 

 

 

The metastasis or spread of cancer is still the main cause of death in cancer patients, and most patients with metastatic cancer can only be treated but cannot be cured
.

Fatty acids are the components of fat in our bodies and the food we eat

The metastasis or spread of cancer is still the main cause of death in cancer patients, and most patients with metastatic cancer can only be treated but cannot be cured

 

 

 

The results of these studies show that one of the fatty acids commonly found in palm oil, palmitic acid, can promote the metastasis of oral cancer and melanoma (a deadly skin cancer) in mice
.

Other fatty acids called oleic acid and linoleic acid - omega-9 and omega-6 fatty acids found in foods such as olive oil and flaxseed - did not show the same effect

The results of these studies show that one of the fatty acids commonly found in palm oil, palmitic acid, can promote the metastasis of oral cancer and melanoma (a deadly skin cancer) in mice

The new study found, to self tumor short-term intake of palmitic acid-rich diet of mice, or in vitro brief exposure to tumor cells palmitic acid, even after serial transplantation (without further exposure to high levels of palmitic acid ), still highly transferable

These authors found that this palmitic acid-induced cancer metastasis memory requires the fatty acid transporter CD36, and the methyltransferase Set1A (as part of the COMPASS complex (Set1A/COMPASS)) caused by histone H3 lysine 4 trimethyl It is related to the stable deposition of basement

RNA sequencing analysis showed that this kind of genes that promote metastasis memory is mainly related to the stimulation of Schwann cells and the innervation of the tumor.

The clinical trial drug being developed is an antibody developed by ONA Therapeutics, which was co-founded by Professor Salvador Aznar-Benitah, the co-corresponding author of the paper

 

Palmitic acid, instead of linoleic acid, oleic acid or stearic acid, can enhance the metastatic potential of oral squamous cell carcinoma for a long time after removal of irritation.
Picture from Nature, 2021, doi:10.
1038/s41586-021-04075-0
.

Palmitic acid, instead of linoleic acid, oleic acid or stearic acid, can enhance the metastatic potential of oral squamous cell carcinoma for a long time after removal of irritation.
Picture from Nature, 2021, doi:10.
1038/s41586-021-04075-0
.

Professor Aznar-Benitah said, “I think it’s still too early to determine what type of diet a metastatic cancer patient consumes can slow the cancer metastasis process
.

In other words, based on our research results, people would think that a diet low in palmitic acid Can effectively slow down the metastasis process, but to determine this requires more research work

Professor Aznar-Benitah said, “I think it’s still too early to determine what type of diet a metastatic cancer patient consumes can slow the cancer metastasis process
.
In other words, based on our research results, people would think that a diet low in palmitic acid Can effectively slow down the metastasis process, but to determine this requires more research work
.
We are not focused on this research direction; instead, we focus on new potential therapeutic targets, we can inhibit these targets, and regardless of the patient’s Regardless of their diet, they can have a real therapeutic effect on them
.
If things go according to plan, we can start the first clinical trial in a few years
.
I am very excited about this and we are investing a lot of energy to produce the best We hope that cancer patients can benefit from it in the near future
.
” According to our research results, people would think that a diet low in palmitic acid can effectively slow down the metastasis process, but more research is needed to determine this
.

Dr.
Helen Rippon, CEO of Worldwide Cancer Research, said, “This discovery is a huge breakthrough in our understanding of how diet and cancer are related, and perhaps more importantly, how we can use this knowledge to get started.
Develop new cancer treatments
.
It is estimated that 90% of cancer deaths are caused by metastasis, and approximately 9 million people die from cancer each year
.
To learn more about the causes of cancer spreading and importantly how to stop it, yes Ways to reduce these deaths
.
Discovery research like this is very exciting because it marks the beginning of a journey that will ultimately save more lives and allow more time to be with loved ones
We are all very much looking forward to seeing the results of this clinical trial and the impact these findings may have on patients with metastatic cancer in the future
.
"

Dr.
Helen Rippon, CEO of Worldwide Cancer Research, said, “This discovery is a huge breakthrough in our understanding of how diet and cancer are related, and perhaps more importantly, how we can use this knowledge to get started.
Develop new cancer treatments
.
It is estimated that 90% of cancer deaths are caused by metastasis, and approximately 9 million people die from cancer each year
.
To learn more about the causes of cancer spreading and importantly how to stop it, yes Ways to reduce these deaths
.
Discovery research like this is very exciting because it marks the beginning of a journey that will ultimately save more lives and allow more time to be with loved ones
We are all very much looking forward to seeing the results of this clinical trial and the impact these findings may have on patients with metastatic cancer in the future
.
"

Reference materials:
Gloria Pascual et al.
Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
Nature, 2021, doi:10.
1038/s41586-021-04075-0.

Reference materials:
Gloria Pascual et al.
Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
Nature, 2021, doi:10.
1038/s41586-021-04075-0.
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