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Picture: A group of Japanese scientists discovered the missing link between chemistry and biology in the origin of life
.
After all, this missing link is not an undiscovered fossil
.
This is a self-replicating tiny sphere called a condensed droplet, developed by two Japanese researchers to represent the evolution from chemistry to biology
They published their findings in the September 24th issue of Nature Communications
.
"Chemical evolution was first proposed in the 1920s.
It is believed that life originated from simple small molecules forming macromolecules, and these macromolecules formed a collection of molecules that can multiply.
Matsuo collaborated with Kensuke Kurihara, a researcher at KYOCERA, to answer a century-old question: How did free-form chemicals on the early earth form life? Like many researchers, they initially thought it was related to the environment: These components are formed under high pressure and high temperature, and then cooled to a more suitable environment for life
.
The problem is spread
Matsuo said: "Diffusion requires self-generating polymer and self-assembly under the same conditions
.
"
They designed and synthesized a new pre-life monomer that uses amino acid derivatives as precursors for self-assembly of primitive cells
.
When these amino acid derivatives are added to room temperature water under normal pressure, they will condense into peptides and then spontaneously form droplets
Matsuo said: "During the origin of life, droplet-based primitive cells can serve as a link between'chemistry' and'biology'
.
" "This research may help explain the emergence of the first organisms on the primitive earth
Researchers plan to continue to study the evolutionary process from amino acid derivatives to primitive living cells, and improve the platform for verification and research on the origin and continuous evolution of life
.
Matsuo said: "By constructing peptide drops that feed on new amino acid derivatives, we have clarified a long-standing mystery experimentally, that is, how the ancestors in the early life stage selectively concentrated the chemicals in the early life stage.
Proliferate and survive
.
" "Compared with the RNA world, we found that the'droplet world' may be a more accurate description, because our research results indicate that the droplets become evolvable molecular aggregates-one of them Became our common ancestor
DOI
10.
