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Written | nagashi editor | Wang Duoyu typesetting | The wisdom of water literati originates from the brain
.
In the final analysis, memory, language, and emotion are derived from a series of electrophysiological activities of the brain
.
As the carrier of consciousness, the brain enables human beings to make instant judgments and reactions to all things and things in the outside world while perceiving the world
.
But unfortunately, the more sophisticated the system often has the heavier the damage price, and the damage is often more difficult to repair
.
For mental diseases such as epilepsy, schizophrenia and depression, the current clinical treatment methods are extremely limited, and the treatment effects for different patients are also very inconsistent
.
Recently, researchers from Massachusetts General Hospital affiliated to Harvard Medical School published a research paper titled: Closed-loop enhancement and neural decoding of cognitive control in humans in Nature Biomedical Engineering, a sub-Journal of Nature
.
In this study, the research team combined artificial intelligence with targeted brain electrical stimulation, showing that precisely directed electrical stimulation can reliably enhance specific human mental functions related to mental illness, and that there are specific sub-capsules in the brain capsule structure.
Part is particularly effective for cognitive enhancement
.
In the end, they proved that the closed-loop algorithm as a controller is twice as effective as a random stimulus
.
Mental illness is a disease that cannot be ignored and will cause a serious medical burden to society and families
.
Clinical studies have shown that brain electrical stimulation can effectively treat mental illness, but unfortunately, the results of clinical neurostimulation tests for mental disorders have been mixed.
This is largely due to the fact that humans’ understanding of brain circuits is still far away.
Far from enough
.
In this study, the research team identified an important brain area-the internal capsule, which is the white matter plate located between the thalamus, caudate nucleus, and lenticular nucleus
.
Researchers have found that the use of trace electrical stimulation on the inner capsule of patients with mental illness can improve the mental function of patients
.
Cognitive conflict and control process review and research status These findings come from a human study conducted by Massachusetts General Hospital on 12 patients undergoing brain surgery for epilepsy
.
The operation places hundreds of tiny electrodes around the patient's brain to record their activity and identify the source of the seizure
.
Interestingly, previous studies have shown that the brain area of the inner capsule is responsible for cognitive control, that is, the process of transitioning from one mode of thinking or behavior to another, which is impaired in most mental illnesses.
.
Professor Alik Widge, the corresponding author of the paper, said: “For example, people with depression often cannot get rid of a negative thought of being'trapped
.
'
Now we find that the brain's internal capsule is so important in mental illness, so , To find a way to improve it may be a powerful new way to treat these diseases
.
” Based on the schematic diagram of the depth electrode (left) and the stimulation target (right), the research team developed an artificial intelligence algorithm to Track the patient’s cognitive control ability after stimulation, either from their behavior or directly from their brain activity
.
Whenever a patient performs poorly in a laboratory test of cognitive control, the controller method increases stimulation
.
Professor Alik Widge said: “This system can read brain activity, “decode” it when the patient encounters difficulties, and then apply small pulses of electrical stimulation to the brain to help them overcome the difficulties
.
I often use an electric bicycle as a metaphor
.
When someone is stepping on it.
When the board has difficulty, the bicycle will perceive and help him
.
We just did something similar
.
"Closed-loop internal capsule stimulation effectively improves cognitive control.
It is worth noting that some patients have obvious anxiety besides epilepsy
.
When given cognitive enhancement stimulation, their anxiety improved because they were better able to transfer their thoughts from pain to what they wanted
.
This indicates that the method can be used to treat patients with severe and drug-resistant anxiety, depression, or other diseases
.
Currently, the research team is preparing for clinical trials
.
Since the goal of improving cognitive control has been approved by the FDA for deep brain stimulation, this research can be completed with existing tools and equipment-once the trial is officially approved, this treatment can quickly be transformed into current medical practice
.
Neural decoding of cognitive state In summary, this research combines artificial intelligence algorithms and brain electrical stimulation therapy to reliably improve the cognitive control of epilepsy patients through precisely directed electrical stimulation of the brain's internal capsule structure.
It can be used in the treatment of anxiety, depression or other mental illnesses
.
As Professor Alik Widge said: "This may represent a new way to treat mental illness
.
We can give patients a tool that allows them to control their thoughts instead of trying to suppress symptoms
.
It's like letting them sit back in the driver's seat and letting them control their own direction
.
”Link to the paper: https:// open for reprinting, welcome to forward to Moments and WeChat groups
.
In the final analysis, memory, language, and emotion are derived from a series of electrophysiological activities of the brain
.
As the carrier of consciousness, the brain enables human beings to make instant judgments and reactions to all things and things in the outside world while perceiving the world
.
But unfortunately, the more sophisticated the system often has the heavier the damage price, and the damage is often more difficult to repair
.
For mental diseases such as epilepsy, schizophrenia and depression, the current clinical treatment methods are extremely limited, and the treatment effects for different patients are also very inconsistent
.
Recently, researchers from Massachusetts General Hospital affiliated to Harvard Medical School published a research paper titled: Closed-loop enhancement and neural decoding of cognitive control in humans in Nature Biomedical Engineering, a sub-Journal of Nature
.
In this study, the research team combined artificial intelligence with targeted brain electrical stimulation, showing that precisely directed electrical stimulation can reliably enhance specific human mental functions related to mental illness, and that there are specific sub-capsules in the brain capsule structure.
Part is particularly effective for cognitive enhancement
.
In the end, they proved that the closed-loop algorithm as a controller is twice as effective as a random stimulus
.
Mental illness is a disease that cannot be ignored and will cause a serious medical burden to society and families
.
Clinical studies have shown that brain electrical stimulation can effectively treat mental illness, but unfortunately, the results of clinical neurostimulation tests for mental disorders have been mixed.
This is largely due to the fact that humans’ understanding of brain circuits is still far away.
Far from enough
.
In this study, the research team identified an important brain area-the internal capsule, which is the white matter plate located between the thalamus, caudate nucleus, and lenticular nucleus
.
Researchers have found that the use of trace electrical stimulation on the inner capsule of patients with mental illness can improve the mental function of patients
.
Cognitive conflict and control process review and research status These findings come from a human study conducted by Massachusetts General Hospital on 12 patients undergoing brain surgery for epilepsy
.
The operation places hundreds of tiny electrodes around the patient's brain to record their activity and identify the source of the seizure
.
Interestingly, previous studies have shown that the brain area of the inner capsule is responsible for cognitive control, that is, the process of transitioning from one mode of thinking or behavior to another, which is impaired in most mental illnesses.
.
Professor Alik Widge, the corresponding author of the paper, said: “For example, people with depression often cannot get rid of a negative thought of being'trapped
.
'
Now we find that the brain's internal capsule is so important in mental illness, so , To find a way to improve it may be a powerful new way to treat these diseases
.
” Based on the schematic diagram of the depth electrode (left) and the stimulation target (right), the research team developed an artificial intelligence algorithm to Track the patient’s cognitive control ability after stimulation, either from their behavior or directly from their brain activity
.
Whenever a patient performs poorly in a laboratory test of cognitive control, the controller method increases stimulation
.
Professor Alik Widge said: “This system can read brain activity, “decode” it when the patient encounters difficulties, and then apply small pulses of electrical stimulation to the brain to help them overcome the difficulties
.
I often use an electric bicycle as a metaphor
.
When someone is stepping on it.
When the board has difficulty, the bicycle will perceive and help him
.
We just did something similar
.
"Closed-loop internal capsule stimulation effectively improves cognitive control.
It is worth noting that some patients have obvious anxiety besides epilepsy
.
When given cognitive enhancement stimulation, their anxiety improved because they were better able to transfer their thoughts from pain to what they wanted
.
This indicates that the method can be used to treat patients with severe and drug-resistant anxiety, depression, or other diseases
.
Currently, the research team is preparing for clinical trials
.
Since the goal of improving cognitive control has been approved by the FDA for deep brain stimulation, this research can be completed with existing tools and equipment-once the trial is officially approved, this treatment can quickly be transformed into current medical practice
.
Neural decoding of cognitive state In summary, this research combines artificial intelligence algorithms and brain electrical stimulation therapy to reliably improve the cognitive control of epilepsy patients through precisely directed electrical stimulation of the brain's internal capsule structure.
It can be used in the treatment of anxiety, depression or other mental illnesses
.
As Professor Alik Widge said: "This may represent a new way to treat mental illness
.
We can give patients a tool that allows them to control their thoughts instead of trying to suppress symptoms
.
It's like letting them sit back in the driver's seat and letting them control their own direction
.
”Link to the paper: https:// open for reprinting, welcome to forward to Moments and WeChat groups
