Nature Sub-Journal | Thirty-year cohort data reminder: middle-aged people sleep less, and dementia can't escape!

Changes in sleep patterns are common in people with dementia, including Alzheimer's disease (AD).

Changes in sleep patterns are common in people with dementia, including Alzheimer's disease (AD).

Both short and long sleep periods are related to cognitive decline and increased risk of dementia.

Most of the evidence for the relationship between sleep time and dementia comes from studies with less than 10 years of follow-up.

Most dementias are characterized by pathophysiological changes occurring in 20 years or more, so long-term follow-up studies are needed to understand the relationship between sleep time and subsequent dementia.

So, will sleep habits in middle age affect the occurrence of Alzheimer's? To this end, experts from the University of Paris in France and the University of London in the United Kingdom used data from the Whitehall II cohort study spanning 30 years to study the relationship between sleep time at the age of 50, 60 and 70 and the occurrence of dementia, and further Explore whether the change pattern of sleep time during this period is related to dementia.

In this study, given that self-reported sleep time may be biased, the researchers examined the relationship between objectively assessed sleep time and the risk of dementia in a subsample of the cohort.

Short sleep time in middle age is related to a higher risk of dementia in the future, and has nothing to do with sociodemographic, behavioral, cardiometabolic and mental health factors.

A total of 7959 participants underwent a 25-year follow-up, of which 521 were eventually diagnosed with dementia.

Compared with normal (7 hours) sleep time, participants who slept for less than 6 hours at the age of 50, 60, and 70 had an increased risk of dementia in old age by 22%, 37%, and 24% (HR = 1.

However, compared with people who continued normal sleep time, sustained short sleep time was associated with the same increased risk of dementia (HR=1.

At the same time, the researchers also pointed out that the correlation between sleep time and dementia has nothing to do with sociodemographic, behavioral, cardiometabolic and mental health factors.

These findings suggest that short sleep time in middle age is associated with an increased risk of late-onset dementia.

Short sleep time in middle age is associated with an increased risk of late-onset dementia.

references:

Sabia, S.

Association of sleep duration in middle and old age with incidence of dementia.

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