[Nature Sub-Journal] When may bacteria develop resistance to antibiotics?

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Author: Ashley Introduction: When may bacteria become resistant to antibiotics? A recent study sequenced the entire genome of more than 3000 tuberculosis (TB) samples.
In this study For the first time, signs of “pre-resistance” of bacteria were found in, which will help doctors to choose the best treatment for bacterial infections in the future
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In a new study led by researchers at UCL (University College London) and Great Ormond Street Hospital (GOSH) in the United Kingdom, scientists have discovered for the first time signs of bacterial'pre-resistance'-which indicates specific Bacteria may become resistant to antibiotics in the future
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The research results were published in the journal Nature Communications, entitled "Genomic signatures of pre-resistance in Mycobacterium tuberculosis", which will allow doctors to choose the best treatment for bacterial infections in the future
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A team led by GOSH and UCL Great Ormond Street Hospital Children’s Health Research Institute cooperated with the Peruvian Tuberculosis Project, funded by Wellcome and the National Institutes of Health, to track tuberculosis (TB) infections through patients for nearly two decades.
The whole genomes of more than 3000 tuberculosis (TB) samples were sequenced
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Mycobacterium tuberculosis (TB) is a bacterial infection that affects the lungs to a large extent
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2020 is the second most infectious cause of death after COVID-19, claiming 1.
5 million lives
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It can be cured if treated with the right antibiotics, but the treatment time is very long, and many people at greatest risk cannot get adequate medical care
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Drug-resistant tuberculosis occurs when people do not complete the entire course of treatment, or when medicines are not available or of poor quality
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Multidrug-resistant tuberculosis is a huge, unsustainable burden, and fully drug-resistant strains have been found in a few countries
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As the health system struggles to cope with the epidemic, progress in global tuberculosis treatment has slowed
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In order to better understand and ultimately better treat tuberculosis, this new study determines for the first time how to prevent drug-resistant mutations before they occur
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Researchers call this concept "pre-resistance": when a disease-causing organism-such as a virus or bacteria-has a greater inherent risk of resistance to the drug in the future
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By analyzing thousands of bacterial genomes, the research has the potential to be applied to other infectious diseases and pave the way for personalized pathogen'genome therapy'-choosing drugs based on the DNA of the specific pathogen causing the disease to prevent drug resistance Produced
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This work is the culmination of a research team led by Dr.
Louis Grandjean, GOSH infectious disease consultant and associate professor at the Institute of Child Health at UCL Grand Ormond Street Hospital in the suburbs of Lima, Peru.
The international research team compared 3135 samples from 3135 different samples.
Tuberculosis samples to reconstruct the phylogenetic tree of tuberculosis bacteria-called phylogeny
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Then, the research team used computational analysis to identify the ancestral genetic code of the bacteria, and then continued to develop drug resistance
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The research team observes the "branch" of the phylogenetic tree to determine the key changes associated with resistance, and see which ones are most likely to continue to develop resistance
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The authors describe how mutations in the TB genome predict that a particular branch will likely develop resistance, and then validated their findings in an independent global TB data set
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The senior author of this international study, Dr.
Grandjean, said: “We have almost no options when it comes to antibiotics.
The choices we have are often toxic-we must use the methods we have more intelligently to prevent resistance
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” It is the first example to show that we can stay ahead of resistance
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This will enable us to use pathogen genomes to choose the best treatment in the future
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"The first author of the paper and PhD student Arturo Torres Ortiz (Child Health Research Institute of Great Ormond Street Hospital, UCL) said: "We hope that this discovery can provide an opportunity by targeting the genomes of specific pathogens that are most likely to develop drug resistance in the future.
A way to treat difficult diseases in the future
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"Reference material: https://medicalxpress.
com/news/2021-12-bacteria-resistant-antibiotics.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
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If you need health guidance, please go to the formal Visit the hospital
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